Effect Of Repetitive Transcranial Magnetic Stimulation Related With Regional Homogeneity In RS-MRI Of Parkinson's Disease

Objective: Parkinson's disease is a degenerative disease of the central nervous system,which is common in the middle-aged and elderly people.It has a high rate of morbidity and disability in China.Medicine is the most important way to relieve symptoms,while both drug and surgery have limitations.Our aim is to obtain the difference of Re Ho value,before and after r TMS treatment.Then we will analyze the related causes and detect the possible pathophysiological mechanisms;We also aim to verify of the efficacy of high frequency r TMS for movement disorder in patients.METHODS: According to the inclusion and exclusion criteria,Seventeen patients diagnosed with PD participated in the study.We complete an rs-f MRI before and after r TMS,as well as the UPDRS scores and MMSE scores in patients.Then Matlab2016 a,DPARSF,and SPSS 22 were used to obtain the final data and images.Results: The UPDRS II/III and motor-related total scores were decreased after 5Hz r TMS treatment,the difference was statistically significant,as well as in the Akinetic-rigid's group.There was an opposite result in the MMSE score.Compared to the data obtained before r TMS,we found that there is an increased Re Ho in the paracingulate gyrus(L),posterior division of the right superior temporal gyrus(R),left cerebellar and the right intracalcarine cortex.There is a decrease in Re Ho value in the right paracingulate gyrus,right anterior division of cingulate gyrus,right posterior division of cingulate gyrus,and left posterior division of the cingulate gyrus.Conclusion:We found that high-frequency r TMS may significantly improve motor behavior in PD patients and the Akinetic-rigid's group.Compared to Re Ho results without r TMS,we saw a difference in the patient's different brain areas,which implies r TMS may promote the visual pathway,the left paracingulate gyrus and the motor conduction pathway,as well as inhibiting the DMN.The main mechanism might be the change in the visual pathway,cortico-cerebellar circuit,and subcortical striatum-cerebellar circuit.