Relationship Between TG / HDL-C Level And In-Stent Restenosis After PCI In ACS Patients

Objective:The purpose of this study was to investigate the relationship between serum TG / HDL-C level and in-stent restenosis in patients with acute coronary syndrome(ACS).Methods:We selected 370 patients who had previously diagnosed ACS and successfully performed drug-eluting stents(DES)in our hospital and reviewed coronary angiography during 2013-2016 as Research object.We retrospectively analyzed eligible patients.The patients were divided into restenosis group(111 cases)and non-restenosis group(259cases).Clinical general data,relevant laboratory tests,and angiographic data of enrolled patients were collected.COX regression model was used to analyze the independent risk factors of coronary stent in-stent restenosis.The receiver operating characteristic The receiver operating characteristic(ROC)curve was used to analyze TG/HDL-C to determine the best cut-off point for in-stent restenosis.Results: The levels of triglyceride / high density lipoprotein(TG / HDL-C)were higher in the in-stent restenosis group than in the non-stent restenosis group(P <0.05).The COX regression analysis showed that the TG / HDL-C(P <0.05 HR: 1.15),bifurcation lesions(P <0.05 HR: 1.722)were independent Risk factors of in-stent restenosis.ROC curve analysis showed that TG / HDL-C = 1.364 was the best cut-off point to judge ISR,with 60% sensitivity and 55% specificity.Conclusions: This study found that TG/HDL-C was independently associated with in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in patients with acute coronary syndromes,but the prognostic value is low.