The Association Study Of Serum Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-l Levels And Acute Cerebral Infarction

Objective: The lectin-like oxidized low-density lipoprotein receptor-l(LOX-1)is a key factor in the process of atherosclerosis,and its soluble molecule(s LOX-1)plays an important role in the process of formation and rupture of atherosclerotic plaque.Recent studies have found that s LOX-1 is highly correlated with acute cardiovascular disease,but the relationship of s LOX-1with cerebrovascular disease is rare.The aim of this study was to investigate the relationship between s LOX-1 and acute cerebral infarction,TOAST classification,disease severity,short-term prognosis and carotid atherosclerosis,and the dynamic evolution of s LOX-1 after acute stroke.Methods: We enrolled 176 patients with acute cerebral infarction,120 patients with carotid atherosclerosis and 80 healthy subjects to collect the peripheral blood samples.In acute cerebral infarction group,the peripheral blood samples were collected again 10 days after onset,called reexamination group.Serum s LOX-1 levels were measured by enzyme linked immunosorbent assay,and the clinical data of patients were collected and grouped.Statistical analysis was performed on s LOX-1 and related data.Results: The level of serum s LOX-1 in ACI group was significantly higher than that in the controls(P<0.001),and the logistic regression analysis showed that s LOX-1 was an independent risk factor for acute cerebral infarction(P=0.001).Serum s LOX-1 levels in the carotid atherosclerosis group were lower than those in the ACIs(P=0.012),and that higher than the controls(P<0.001).According to Toast classification group found that the level of serum s LOX-1 in patients with large arterial atherosclerotic cerebral infarction was higher than that in patients with small arterial occlusion(P=0.027).The level of sLOX-1 was positively correlated with NIHSS score(P<0.001)and intracranial infarction lesion volume(P<0.001).The s LOX-1 levels in unstable carotid plaque group were higher than those in non-unstable plaque group(P=0.030);the level of serum s LOX-1 in carotid stenosis group was higher than those in non-carotid artery stenosis group(P=0.023).The level of serum s LOX-1 in the review group was higher than that in the controls(P=0.030),and lower than those in the ACIs(P<0.001),and has no significant difference with the carotid atherosclerosis group(P=0.080).The recovery of neurological deficit was positively correlated with the decline of s LOX-1 level on the 10 th day of onset.(P<0.001).Conclusion: 1.Serum levels of s LOX-1 were significantly increased in patients with acute cerebral infarction,and positively correlated with Toast classification,volume of cerebral infarction and severity of neurological deficits.2.Serum s LOX-1 levels in acute cerebral infarction group were correlated with carotid plaque type and carotid artery stenosis.3.Serum levels of sLOX-1 in acute cerebral infarction group showed dynamic fluctuations,increased significantly in acute phase,and then decreased.The decreased level of s LOX-1 was no difference compared with that in carotid atherosclerosis group,but still higher than that in healthy control group.4.The dynamic changes of s LOX-1 level were correlated with the short-term prognosis of acute cerebral infarction group.Therefore,serum s LOX-1 may be used as a serum marker for assessing severity of illness and predicting short-term prognosis in acute cerebral infarction.