The Significance Of Thrombolysis In Gestational Diabetes Pregnant Women With High Blood Coagulation State

ObjectiveTo detect gestational diabetes patients blood coagulation indexes and thrombelastogram,and to explore the change and significance of coagulation index and thrombelastogram with gestational diabetes mellitus.Methods1.From Jan 2014 to May 2015 women with gestational diabetes mellitus 120 cases were collected by Affliated Hospital of Qingdao University for this study,and The 120 cases of normal pregnant women were randomly selected as control group.Eliminate suffering from diseases of the blood system,immune system disease,pregnancy with diabetes,abnormal liver function,renal function abnormalities,hyperthyroidism,heart disease,arrhythmia obviously,gestational hypertension disease,such as mother son blood type is acute or chronic illness.None of the above pregnant women have taken oral drugs that affect the function of coagulation.2.Both groups were recorded simultaneously the gestational age,height,fasting plasma glucose(FPG),blood lipid levels(triglycerides TG,TC,HDL cholesterol,HDL-C,low density lipoprotein LDL-C,very low density lipoprotein(VLDL-c),blood clots elastic graph parameters(reaction time R value K,and clotting time,alpha Angle of blood clot formation rate,maximum amplitude MA)and routine blood,blood clotting index(platelet count PLT,fibrinogen FIB,D-dimer,prothrombin time,partial PT activated APTT).3.The changes of fasting blood glucose and blood lipid were determined by automatic biochemical analyzer.We used thrombelastogram analyzer to detect thrombelastogram index and full automatic blood coagulation instrument to detect coagulation indicator with groups of pregnant women.Platelets were examined by routine blood analyzer.4.USES SPSS22.0 software,The measurement data was expressed by plus or minus s,and the t-test of two independent samples was used for comparison between groups;After normal test,the normal data was analyzed by pearson correlation analysis,and spearman correlation analysis was adopted in the non-normal data,and P <0.05 was considered statistical significance,and P <0.01 suggested that the difference was statistically significantResults1.The basic data of gestational diabetes mellitus group and control group showed that There was no statistical difference between age,gestational age and height(P>0.05).2.Compared with the control group,the GDM group FPG was significantly increased(P<0.05),and there was no statistical difference between TG,TC,hdl-c,ldl-c and vldl-c(P>0.05).3.There was no statistical difference in PLT count in GDM group and healthy pregnant group(P>0.05).4.The APTT and PT of GDM group were significantly decreased compared with that of normal pregnant group(P < 0.05).D-dimer and FIB increased significantly(P < 0.05).5.The parameters of TEG in the gestational diabetes group were significantly lower than that in the control group(P < 0.05).The Angle and MA values were significantly higher(P < 0.05).6.The related parameters of TEG in gestational diabetes group had a linear correlation with some commonly used coagulation indicators,K value and APTT as positive correlation(P< 0.05);The alpha Angle is positively correlated with PLT(P <0.01);MA value and FIB were positive correlation(P < 0.01).ConclusionsPregnant women with gestational diabetes have high blood clotting.TEG is an useful indicator for monitoring the gestational diabetes blood coagulation state.TEG has linear correlation with some commonly used coagulation indicators.