The Effects Of Anti-depressant Drugs Therapy On Quality Of Life And Symptoms Of Patients With Refractory Irritable Bowel Syndrome

Objective:The aim of this study was to examine the effects of anti-depressant drugs therapy associated with conventional drugs therapy in comparison to conventional drugs therapy alone on the QOL and symptoms of refractory irritable bowel syndrome patients.Methods:This study was a randomized clinical trial on 80 refractory irritable bowel syndrome patients.The patients were selected according to Rome criteria and of Gastroenterology of Qingdao Municipal Hospital,with 40 cases in study group and 40 cases in control group.IBS-QOL?SAS?SDS?IBS-SSS were used to investigate the patients' symptoms of mental health and quality of life.The first group underwent anti-depressant drugs(paroxetine)therapy associated with conventional drugs therapy,and the second group received only conventional drugs therapy alone.Results:(1)At the end of treatment,the scores of IBS-SSS of the experimental group(188.70.±64.63)was significantly lower than the control group(261.35±71.14,t=3.129,P =0.002).(2)At the end of the study,the scores of SAS of the experimental group(44.33±10.78)was significant lower than the control group(52.23±13.37,t=-2.927,P =0.004)?(3)At the end of the study,the scores of SDS of the experimental group(37.38±9.08)was significant lower than the control group(49.75±13.17,t=-4.892,P =0.000)?(4)At the end of the stud,the scores of IBS-QOL of the experimental group(73.70±11.47)significantly improved than the control group(64.45±12.50,t=2.689,P =0.009)?(5)The scores of SAS?SDS and IBS-SSS of the experimental group was significant lower than the control group(t=3.001,p=0.004? t=5.376,P =0.000?t=5.663,P =0.000);The scores of IBS-QOL significantly improved(t=-5.510,P =0.000)?(6)At the end of the treatment,there was no contrast difference of The scores of SAS?SDS and IBS-SSS of the control group(t=0.017,P =0.986?t=0.740,P =0.461?t=0.823,P =0.413),and The scores of IBS-QOL significantly improved(t=-3.844,P =0.000). Conclusion:(1)Anti-depressant drugs can significantly improve treatment effect of the patients with refractory irritable bowel syndrome.(2)Anti-depressant drugs can significantly improve anxiety and depression of the patients with refractory irritable bowel syndrome(3)Anti-depressant drugs can significantly improve the quality of life of the patients with refractory irritable bowel syndrome.(4)Conventional drugs therapy can improve the quality of life of the patients with refractory irritable bowel syndrome.(5)Conventional drugs therapy can not improve symptoms or anxiety and depression of the patients with refractory irritable bowel syndrome.