A Retrospective Study Of Atherosclerotic Cardio-Cerebral Vascular Diseases In Patients With Metabolic Syndrome Of Different BMI

Objective:This study retrospectively analyzed the clinical data of patients with metabolic syndro me(MS)enrolled to our hospital from April 2009 to April 2015.The clinical features of MS patients with different body mass index(BMI)and combined atherosclerotic cardio-cerebral vascular disease(ASCVD)were observed.Explore the correlation between BMI and ASCVD,and provide new ideas for the prevention and treatment of MS and related ASCVD.Methods:2027 cases of MS who were from April 2009 to April 2015 were divided into nor mal weight(n = 492),overweight(n = 996)and obese group(n = 602).Then counting up the general physical measurement data(including hospitalization number,name,gender,age,height,weight,waist circumference,hip circumference,blood pressure),biochemical indicators(including blood sugar,blood fat)and cardiovascular and cerebrovascular dise ases(including coronary artery disease,cerebrovascular accident,macro-vascular atheroscl erosis).Differences of sex,age,pulse pressure(PP),Waist-to-hip ratio(WHR),fasting bl ood glucose(FBG),triglycerides(TG),total cholesterol(TC),low density lipoprotein(LDL-C)and high density lipoprotein(HDL-C)were analyzed in the three groups.The prevalence of atherosclerotic cardiovascular diseases(ACD),cerebrovascular accident(CVA)and mac ro-vascular arteriosclerosis(AS)was compared in the three groups.The logistic regression analysis was performed on the risk factors associated with ASCVD in MS patients.Results: 1.2017 cases are studied in this research.2.The basic situation of the cases: 1190 cases of male,837 cases of female.The average age of all cases is 57.33±12.88 years old.3.Body measurements and laboratory tests: The composition ratio of abnormal BMI in M S patients is higher than that of normal BMI,and it is more significant in males.The av erage WHR of all cases is 0.98±0.46,and the mean pulse pressure is 55.80±25.90.There is no difference between the three groups.The average FBG is 9.31±4.08,the average TG is 2.77±2.85,and the average TC is 4.93±1.68.The mean LDL-C is 2.88±1.03,and th e mean HDL-C is 1.10±1.24.There is only difference in TG between groups.4.MS Composition: Among the 736 patients(36.31%)who meets three MS components,791(39.02%)who meets four MS components,and 500(24.67%)who meets five MS components.The metabolic abnormalities in the three groups mainly manifested as elevated bl ood glucose,followed by increased waist circumference and blood pressure,with obesity b eing the most significant.5.Dyslipidemia: There are 842 cases(41.54%)with hypertriglyceridemia,439 cases(21.66%)with hypercholesterolemia,521 cases(25.70%)with High LDL-C hyperlipidemia,an d 653 cases(32.22%)with low HDL-C hyperlipidemia.With the increase of body mass index,the incidence of hypertriglyceridemia and low HDL-C hyperlipidemia was increase d.In the same group,the incidence of hypertriglyceridemia and low HDL-C hyperlipidemi a was in the top two.6.There was no significant difference in the incidence of ACD,CVA and AS between th e three groups.7.Through one-way analysis of variance,the risk factors for ASCVD in patients with MS include age,sex,BMI,pulse pressure,TG,and LDL-C.Logistic multivariate regression analysis showed that age was an independent risk factor for ASCVD.And BMI was not an independent risk factor for ASCVD,it′s interaction with various risk factors affected t he occurrence of ASCVD.8.The risk of ASCVD in MS patients with normal body weight was not significantly diff erent from that in overweight and obese patients.Conclusions:No significant difference in ASCVD risk among MS patients with different BMI.MS patients with normal BMI had the same risk of ASCVD as MS patients with abnormal BMI.