| Objective: To figure out the trend of maternal serum selenium during gestation and postpartum period,and analyze the correlation between maternal selenium with maternal and offspring's thyroid related indicators,and the impact on pregnancy complications.Methods: The serum concentration of maternal selenium,thyroid related indicators,urine iodine and cord blood thyroid related indicators and offspring's physical development were measured in 133 pregnant women from Dandong where Subclinical hypothyroid in early pregnancy(SHEP)project were implemented at 8,20,36 weeks of gestation and 3,6 and 12 months after delivery.Spot blood and urine samples were obtained from each participant in the morning after an overnight fasting.The serum selenium concentrations were measured with an inductively coupled plasma mass spectrometer(ICP-MS).Results: The serum selenium concentration decreased gradually from the 8th week to the 36 th week,reached the lowest level at the 36 th week,and then increased significantly at 3 months after delivery and the postpartum selenium concentration tend to be stable.Spearman rank correlation analysis and multivariate linear regression analysis showed that TSH was positively correlated with selenium at 6 months after delivery,FT4 was positively correlated with selenium at 3 months after delivery,FT3/FT4 ratio was negatively correlated with selenium at 3 months and 6 months after delivery,TT3/TT4 ratio was negatively correlated with selenium at 8th week during pregnancy.Spearman rank correlation analysis and multivariate linear regression analysis showed that cord blood FT4 was positively correlated with selenium at 20 th week during pregnancy,cord blood FT3 was positively correlated with selenium at 36 th week during pregnancy,cord blood TT3 was positively correlated with selenium at 20 th week during pregnancy,cord blood Tg was positively correlated with selenium at 36 th week during pregnancy.There was a statistically significant difference among different concentration level in the incidence of spontaneous abortion at 12 month postpartum.There was no significant difference inmaternal selenium concentrations between the two groups with or without complications of pregnancy and negative pregnancy outcome.We did not find significant correlation between serum selenium concentration and physical development of offspring.Conclusion: The serum selenium concentration showed a significant trend with the course of pregnancy,and returned to normal 3 months after delivery.Serum selenium concentration is correlated with some maternal and fetal thyroid-related indicators,and it may affect thyroid function through selenium-containing enzymes.Serum selenium levels during pregnancy have little effect on adverse pregnancy outcomes and offspring physical development. |
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