| Objective:1.The efficacy and safety of intravitreal injection of Conbercept in the treatment of BRVO-ME.2.To explore the difference of treatment effect between BRVO-ME and BRVO-ME with macular SRD.Method:38 eyes of 38 patients with BRVO-ME were included in the study.Macular edema was examined by coherence tomography(OCT).The patients were divided into two groups: SRD(+)and SRD(-)group.Both groups were treated with intravitreous injection of Conbercept(0.05ml).Programme1+PRN.Both initial injection one time,later as needed treatment.The condition satisfied by PRN was that the macular foveal thickness and central macular thickness(CMT)> 250 um and / or macular edema were tower than those of CMT > 50 um and / or The best corrected visual acuity is less than the previous examination.The changes of BCVA,CMT before treatment and 1,3,6months after treatment were compared between the two groups.Results:SRD(+)group(n = 16)and SRD(-)group(n = 22).Before treatment,the CMT(663.2 ±182.9)um of SRD(+)group was greater than that of SRD(-)group(459.2 ±152.2)um),There is statistical difference.(P < 0.05).BCVA(0.89±0.33)in SRD(+)group was worse than that in SRD(-)group(0.59±0.24),There is statistical difference.(P < 0.05).After 1 month,3 months and6 months of intravitreous injection,the BCVA of the SRD(+)group were(0.42 ±0.26),(0.32 ±0.21)and(0.24 ±0.15),respectively,which were significantly improved compared with those before the operation(P < 0.05).At1 month,3 months and 6 months after operation,the BCVA of the SRD(-)group was(0.40 ±0.21),(0.36 ±0.23),(0.27 ±0.26),There was significant improvement compared with preoperation.,and the difference was statistically significant(P < 0.05).There was no significant difference in visual acuity between the two groups at 1,3,6 months postoperatively(P > 0.05).After intravitreal injection of 1,3,6month,the CMT of SRD(+)group was(349.7 +201.9)um,(306.1 + 188.2)um,(272.1 + 71.0)um,which was significantly lower than that before operation,and the difference was statistically significant(P< 0.05).the CMT of SRD(-)group was(322.9±132.7)um,(310.9±125.1)um,(287.9±88.3)um,which was significantly lower than that before operation,and the difference was statistically significant(P<0.05).There was significant difference between the two groups(P <0.05).There was no significant difference in CMT between the two groups at 1month,3 months and 6 months postoperatively(P > 0.05).CMT decreased at 1,3 and 6 months after operation compared with preoperative:In the SRD(+)group,it was(324.6 ±201.31),(351.2 ±184.1)and(380.4 ±166.3)um,respectively.SRD(-)group,it was(161.8±142.2),(171.7±133.8)and(197.5±142.2)um,respectively.There were significant differences among groups in each month(P< 0.05).BCVAlogMAR increased at 1,3 and 6 months after operation compared with preoperative:SRD(+)were(0.32 ±0.26),(0.48±0.21),(0.58 ±0.35),respectively.There were significant differences among groups in each month(P < 0.05).Conclusion:The degree of visual impairment and macular edema in BRVO patients with SRD was more serious than that in BRVO patients with CME.The effect of intravitreal injection of Compactopril on BRVO with macular edema was obvious,and there was no difference in BCVA and CMT between the two groups.But the improvement of BCVA and CMT in patients with SRD was greater than that in patients with CME alone. |
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