Study On The Correlation Between Blood Platelet Count And Efficacy After The Induction Chemotherapy In Patients With Acute Myeloid Leukemia

Objective:To analyze the change of platelet count after induction of chemotherapy in patients with diagnosed acute myeloid leukemia,evaluate its correlation with bone marrow remission,and explore early indicators that predict the efficacy of AML.Methods:Collection of clinical data of 152 patients diagnosed as AML and undergoing standard DA chemotherapy from Department of Hematology,First Affiliated Hospital,Shihezi University from January 2010 to December 2016,excluding palliative care,non-standard chemotherapy,and Acute Promyelocytic Leukemia(APL),diseases such as myelodysplastic syndrome(MDS)and bone marrow-derived(MPN)tumors are converted to AML and treatment-related leukemia.According to the bone marrow remission at the 14th day after the end of chemotherapy,there were 92 cases of complete remission(CR)and 60 cases of incomplete remission(PR+NR).The gender,age,white blood cell count(WBC),hemoglobin concentration(HB),platelet count(PLT)at the first visit,and PLT count data at the early bone marrow recovery(10th)and the fully convalescent(14th)days after the end of chemotherapy were collected.SPSS 19.0 statistics software were used for data processing,the measurement data does not conform to the normal distribution to M(p25,p75),compared to the use of rank and test,counting data are expressed in terms of frequency and percentage,and compared with X~2 test.Results:There was no significant difference in the gender,the hemoglobin concentration,the platelet count and the CR rate of the patients with different bone marrow relieving group after the induction chemotherapy in the diagnosed AML patients(P>0.05);The total CR rate in patients with incomplete bone marrow remission after induction chemotherapy was?60 years old,the white blood cell count at the initial visit was?30×10~9/L,and the total CR rate was significantly lower than those without the first induction(P<0.05);By dynamically observing the changes of platelet counts on the 10th and 14th days after the end of chemotherapy,the PLT co unts in 92 patients with bone marrow complete remission were higher than those in 60 patients with incomplete remission(P<0.05);On the 10th day after chemotherapy,92 patients with complete remission group(76cases)were PLT?20×10~9/L,of which 42>50×10~9/L;60 cases were not completely relieved in 32 cases?20×10~9/L,only 10 cases>50×10~9/L(P<0.05);At the 14th dayafter chemotherapy,the proportion of PLT?100×10~9/L was significantly higher in the bone marrow complete remission group than in the incomplete remission group(P<0.01).Conclusion:1.Gender,initial hemoglobin concentration,and platelet count of diagnosed AML patients were not related to bone marrow remission rate;2.AML patients aged?60 years,white blood cell count at the time of first visit?30×10~9/L,and first induction of non-CR-The total CR rate was significantly lower than those without the above factors;3.The dynamic change of plateletc ount after induction of chemotherapy in diagnosed AML patients has a certain correlation with the recovery of bone marrow hematopoietic function.The increase of platelet count after chemotherapy is relatively effective,and can be used as a simple clinical assessment of the efficacy of AML One of the monitoring indicators.