Analysis Of Relevant Factors In Remission Of First Induction Chemotherapy In Acute Myeloid Leukemia

OBJECTIVE:To analyze the remission rate after first induction chemotherapy and related influencing factors in patients newly diagnosed with acute myeloid leukemia(AML)at the Affiliated Hospital of Binzhou Medical College,to understand the characteristics of acute myeloid leukemia in the region and to determine a variety of factors,may be more targeted individualized therapy,chemotherapy,help to improve response rates,provide theoretical data for the study of molecular targeted drugs,and acute myeloid subsequent consolidation chemotherapy,bone marrow transplantation,leukemia patients provide a good condition.METHODS:From July 01,2014 to July 31,2017,98 patients with acute myeloid leukemia(except acute promyelocytic leukemia)who were newly diagnosed at the Affiliated Hospital of Binzhou Medical College were selected for general information(age,gender).,Signs,and found through the DNA sequencing FLT3-ITD,NPM1,IDH1,IDH2,WT1,KIT,CEBPA,CBF ?-MYH11 and other related gene mutations,collecting karyotype,peripheral blood characteristics and mitigation.The univariate logistic regression analysis was used to identify the relevant factors of remission rate,and the relationship between the relevant factors was analyzed.Results:A total of 98 newly diagnosed AML patients were collected in this study.Among them,91 cases had complete data and the effective rate was 92.86%.These 98 patients met the diagnostic criteria for acute myeloid leukemia(except for acute promyelocytic leukemia),of which 49 patients with acute myeloid leukemia did not respond after the first chemotherapy and 42 patients with acute myeloid leukemia achieved complete remission.By single-factor analysis of the factors associated with the response rate of the first diagnosis of acute myeloid leukemia patients after the first chemotherapy,including white blood cell count,extramedullary infiltration,karyotype,FLT3-ITD,NPM1 and so on.Conclusion:The study found that accompanied by extramedullary infiltration,karyotypic abnormalities,FLT3-TID gene mutation,and leukocytosis had a poorer effect on the prognosis of patients with acute myeloid leukemia after the first induction chemotherapy.Patients with acute myeloid leukemia with positive NPM1 mutations have a better prognosis.Patients with karyotypic abnormalities and NPM1-positive acute myeloid leukemia are often accompanied by an increase in leukocytes.There was no significant correlation between the presence or absence of mutations in the genes examined and the karyotype abnormalities.It is recommended to increase the analysis of other relevant factors in patients with acute myeloid leukemia and increase the sample size of patients with acute myeloid leukemia for further analysis.