| Objective :To investigate the status of ?-blocker prescription,anaslsis the resting heart rate controlling status and factors influencing the use of ?-blocker in hospitalized patients with coronary heart disease,heart failure,hypertension.Methods :A total of 1992 inpatients were enrolled from December 2015 to June 2017.Generally clinical data,the current situation of clinical use of ?-blocker were analyzed,Analysis of the general situation of patients with coronary heart disease,heart failure,hypertension and so on;according to the medication situation,patients were divided three groups by metoprolol tartrate tablets,metoprolol succinate sustained release sablets and bisoprolol fumarate tablets comparsion the RHR of three groups recorded on the day of admission and discharge and successful rates of RHR were calculated.To analyze the factors related to the use of ?-blocker in the Chinese subgroup of CLARIFY.Undertake short-term follow-up for discharged patientsResults :(1)The basic clinical characteristics:Totally of 1992 inpatients were enrolled.The average age was(62.79±11.68)years old with 1305(65.51%)male patients,687(34.49%)female patients,average length of hospitalisation is(11.78±5.81)days.Among the hospitalized patients,1378cases(69.18%)took ?-blocker,580 cases(42.09%)took metoprolol tartrate Tablets,454 patients of metoprolol succinate tablets(32.95%),and bisoprolol tablets 344 cases(24.96%).(2)Analysis of the general situation of patients with coronary heart disease,heart failure and hypertension:The age of the patients in the taking group was younger than that of the no taking group(59.70±11.18vs71.32±7.94,61.80±10.81vs72.06±8.37,60.70±10.35vs71.98±6.96,P<0.05).The rate of resting heart rate is fast at admission than that of the no taking group(78.17±13.74vs75.25±17.45,79.07±14.93vs76.63±20.34,78.37±13.10vs72.94±16.92P<0.05),taking group smoking(56.27%vs 37.56%,51.57%vs40.68%,51.52%vs29.50%,P<0.05).(3)Analysis of influencing factors:Multivariate regression analysis showed that the use of ?-blocker was significantly lower in the old age than the young age,.smoking and fasting baseline heart rate were related to higher percentage of?-blocker use(P<0.05).(4)Resting heart rate comparison during admission and discharge: RHR of three groups on admission was significantly lower than discharge(67.10±6.14 vs 74.68±11.79,67.86±5.79 vs80.26±13.76,67.94±6.07 vs 80.86±13.67,P<0.05).The rate of resting heart rate in the three groups was respectively15.37%?11.46%?12.85%.(5)Follow-up results:All 1591 outpatients completed the follow-up study at the median of 6 months,including 1386 people who Insisted taking drugs,106 people stopped taking drugs because of personal economic reasons,15 people who stopped taking drugs because of adverse drug reactions,73 people who stopped taking drugs because of other reasons.Conclusions :At present,The rate of ?-blocker usage was low in patients with coronary heart disease,heart failure and hypertension in our hospital,middle and small doses of drugs were mainly used during hospitalization,the resting heart rate at discharge is lower than that at the time of admission,successful rates of RHR were lower than the target suggested. |
PDF Full Text Request