Effect Of Dexmedetomidine On Cerebral Vessel Diameter And Cerebral Oxygen Metabolism In Neurosurgical Patients Undergoing DSA Examination

Objective:To observe the effects of dexmedetomidine on cerebral vessel diameter and cerebral oxygen metabolism in neurosurgical patients undergoing DSA examination.Methods:A total of 60 patients undergoing DSA examination(group dexmedetomidine,n = 30 and group normal saline,n = 30)were enrolled in the study.Dexmedetomidine infusion(1 ug/kg)over 15 min was given as a loading dose in group dexmedetomidine while normal saline was given in the control group.Cerebral vessel diameter was noted after loading dose of dexmedetomidine/saline(T3)in each group.Blood samples from jugular bulb and radial artery were taken to determine cerebral extraction of oxygen(CERO2).Ramsay sedation scores,circulation and respiratory parameters were noted at baseline(T0),5min(T1),10min(T2)and 15min(T3)after starting the loading dose.Results:Compared with the control group,cerebral vessel diameter and CERO2 were significantly decreased at 15 min after adminstration of dexmedetomidine.Compared with the control group,The HR and MAP after administration 5,10,15 min in trial group was decreased(P<0.05),whereas the R and SpO2 were not statistically significant between the two groups.Ramsay sedation scores at 15 mins after adminstration of dexmedetomidine were significantly higher than those before sedation and the control group(P<0.05).Conclusion:Dexmedetomidine is an effective drug used for conscious sedation and decreases cerebral vessel diameter and cerebral oxygen metabolism in neurosurgical patients undergoing DSA examination.