Altered Spontaneous Brain Activity Of Resting-state FMRI In Migraine Patients:a Meta-analysis

Objective:Migraine is one common primary headache.Under resting-state functional magnetic reasonance imaging(rs-f MRI),the amplitude of low-frequency fluctuation(ALFF)value and regional homegeneity(ReHo)value in different brain regions can be calculated.It is found that ALFF and ReHo of migraine patients had significant differences when compared with those of healthy controls.But abnormal brain regions reported by various institutes were quite different.In this study,meta-analysis was used to integrate and analyze ALFF value and ReHo value to investigate the characteristics and regularities of spontaneous brain activity in migraineurs.Methods:The included literatures about resting-state fMRI study for migraine patients with altered brain function were searched in PubMed,EBSCO host medline,Web of Knowledge,Science Direct,EMBASE,Cochrane Library,CBMdisc,CNKI,Wanfang databases.According to the systematic review method,two researchers independently performed the screening of the literatures,evaluated the quality and extracted data.Signed differential mapping(SDM)software was used for voxel based pooled meta —analysis of ALFF and ReHo.Results:A total of 13 articles were adopted in the study,including 6 articles on ALFF,6articles on ReHo,and 1 article on both.7 studies comprising 191 patients with migraine and 166 healthy controls were included in a meta-analysis of ALFF.The heterogeneity difference between the seven papers was not statistically significant(P>0.1).Meta-analysis showed ALFF increased in migraine patients compared with healthy controls.It was mainly distributed in bilateral insula,left anterior thalamic projections.While ALFF decreased in corpus callosum,left inferior frontal gyrus(including orbital part),right middle occipital gyrus,left inferior parietal gyri of migraine patients’.7 articles were included in meta-analysis of ReHo,containing 151 migraineurs and150 healthy subjects.There was no significant heterogeneity difference among the studies(P>0.1).The results showed that compared with the healthy subjects,ReHo of migraine patients increased in right angular gyrus,left cerebellum(hemispheric lobule VIII),right cuneus cortex,but decreased in left cerebellum(hemispheric lobule IV / V),left median cingulate / paracingulate gyri,right precentral gyrus.Conclusion:Migraine patients have abnormal activities in multiple brain regions under resting state.These abnormal brain regions play an important role in the pathogenesis of migraine.