Relationship Between Platelet And Lymphocyte Ratio And Coronary Atherosclerotic Lesions

Objective:The possible role of PLR in coronary atherosclerosis was explored by analyzing the change of platelet/lymphocyte ratio(PLR)and its correlation with coronary artery disease.Methods:A retrospective analysis of 243 patients diagnosed as coronary heart disease from March 2016 to March 2017 in the second clinical hospital of shanxi medical university and the collection of 100 healthy patients in the same period as the study subjects were divided into two groups:(1)100 healthy check-up patients as the control group,(2)243patients diagnosed as coronary heart disease were experimental group.By comparing the general clinical data and the platelet/lymphocyte ratio(PLR)between the two groups,the relationship between the changes of PLR and coronary heart disease was preliminarily understood;then the coronary heart disease was diagnosed according to the criteria of stable angina and acute coronary syndrome.Heart disease patients were divided into 2groups:(1)stable angina group(97 cases),(2)acute coronary syndrome group(146cases),and further comparison of general clinical data and test index differences between the two groups,regression analysis PLR Correlation with the degree of coronary artery disease.Results:(1)Compared with the healthy control group,the average leukocyte count in the coronary artery disease group was 7.7±2.7×109 higher than that in the healthy control group 5.9±1.4×109,and the platelet/lymphocyte ratio 128.6±72.4 was higher than the healthy control group 112.8±36.4.The difference was statistically significant(P<0.05).There was no statistical difference in gender,age,lymphocyte count and platelet count between the two groups.(2)The Gensini score of the acute coronary syndrome group(ACS)was 44.85±35.47 higher than that of the stable angina group(20.45±14.17).There was a statistically significant difference between the two groups(P<0.05),gender,age,body mass index,smoking rate,The incidence of hypertension and the incidence of diabetes were not statistically significant.(3)Fasting plasma glucose(FPG)was 6.45±2.42 mmol/L in the acute coronary syndrome group(ACS),5.78±1.28mmol/L in the stable angina group,and 8.33±2.95×109 in white blood cells(WBC)was higher than stable angina pectoris.In group 6.80±1.99×109,platelet/lymphocyte ratio(PLR)was 142.83±83.57 higher than stable angina group 107.17±43.72,lymphocyte(Lym)1.88±0.74×109 was lower than stable angina group 2.19±0.79×109,There was a statistically significant difference between the two groups(P<0.05).The remaining tests were homocysteine(Hcy),platelet count(PLT),total cholesterol(TC),triglyceride(TG),and high-density lipoprotein(HDL).),LDL,creatinine(Cr),urea nitrogen(BUN),and serum uric acid(UA)were not statistically different between the two groups.(4)Pearson correlation analysis showed that PLR was positively correlated with Gensini score in patients with stable angina(r=0.201,P<0.05).PLR was positively correlated with Gensini score in patients with acute coronary syndrome(r=0.336).P<0.05).Conclusion:The PLR value of patients with coronary heart disease was higher than that of the healthy control group.It was confirmed that the inflammatory reaction may play an important role in the development of atherosclerosis.PLR may predict the degree of coronary artery stenosis in patients with coronary artery disease,especially the degree of inflammation of acute coronary syndrome.PLR assessment of risk in patients with acute coronary syndrome may be a good predictor.