Association Of Mean Platelet Volume-to-lymphocyte Ratio With The Severity Of Coronary Lesion In Patients With Acute Coronary Syndrome And In Diabetic Patients With Acute Coronary Syndrome

Objective: By collecting and analyzing the average platelet volume and lymphocyte ratio(Mean Platelet Volume-to-Lymphocyte Ratio,MPVLR)in patients with acute coronary syndromes(ACS)and type 2 diabetes mellitus(T2DM),SYNTAX score was used to evaluate the severity of coronary artery disease,and the correlation between MPVLR and severity of coronary artery disease in patients with ACS and T2 DM was studied.Methods:155 patients with ACS diagnosed by coronary angiography at the Dongguan Branch of Yan’an University Hospital from March 2017 to June 2018 were enrolled,including 74 patients in the ACS group and 81 patients in the ACS group and T2 DM group.Group,ACS combined with T2 DM as the study group.SYNTAX scores were calculated according to coronary angiography in both groups,and ACS combined with T2 DM scores were milder(<23 points,low-risk group)and coronary artery lesions were more severe according to SYNTAX score(SYNTAX score ≧23).,high risk group).All patients were admitted to the hospital without taking the platelet count and platelet volume,and the experienced nurses quickly took peripheral venous blood and sent them to the Yan’an University Dongguan Branch for testing MPVLR and other laboratory data.To analyze the differences between general data and MPVLR in patients with ACS alone and ACS combined with T2 DM,and to analyze the factors affecting the severity of coronary artery lesions in patients with ACS and T2 DM by multivariate logistic regression analysis and ROC curve,and to summarize the patients with MPVLR and ACS combined with T2 DM.The relationship between the severity of coronary lesions and the SYNTAX score.Results:1.There was no difference in Lymphocyte count(LYM),platelet count and lymphocyte ratio(PLR)between the ACS group and the ACS group(P>0.05).The two groups were compared with neutrophilic granulocyte(neutrophilic granulocyte,neutrophilic granulocyte).NE),platelet(Platelet,PLT),mean platelet volume(MPV),and MPVLR were statistically significant(P<0.05).The MPV of patients in the ACS group was lower than that of the ACS plus T2 DM group,which were 10.50±1.22 and 12.62±2.28,respectively.The difference was statistically significant.The MPVLR of the ACS group was lower than that of the ACS combined with the T2 DM group,which were 6.73±2.48 and 8.03±2.85,respectively.The difference is statistically significant.The SYNTAX scores of patients with ACS combined with T2 DM were higher than those of patients with ACS alone.The values of the two groups were 16.07±7.30 and 19.70±9.59,respectively.The difference was statistically significant.2.There was a correlation between LYM,PLR,MPVLR and SACS in patients with ACS and T2 DM in the T2 DM group(r=-0.652,r=0.466,r=0.675,P<0.05).3.In the ACS combined T2 DM group,the SYNTAX score was used as the dependent variable,and the binary multivariate logistic analysis was performed.The regression coefficient of PLR was 0.036,OR value: 1.037,P=0.007<0.05.Regression coefficient of MPVLR: 1.029,OR value: 2.798,P=0.012<0.05.Regression coefficient of LYM: 1.341,OR value: 3.825,P=0.473.This indicates that PLR and MPVLR are independent risk factors for assessing the severity of coronary artery disease in patients with ACS and T2 DM.4.The best cutoff value of PLR in the diagnosis of coronary artery lesions in patients with ACS complicated with T2 DM was 115.97,sensitivity: 81.1%,specificity: 70.5%,area under the curve was 0.792,95% CI(0.694,0.890).The best cutoff value for MPVLR diagnosis of severity of coronary artery disease in patients with ACS and T2 DM was 7.62,sensitivity: 89.2%,specificity: 81.8%,area under the curve was 0.882,95% CI(0.806,0.958).The value of MPVLR is superior to PLR in diagnosing the severity of coronary lesions in patients with ACS and T2 DM.Conclusions :1.There was a positive correlation between MPVLR,PLR and ACS combined with T2 DM coronary lesion severity.There was a negative correlation between LYM and ACS combined with T2 DM coronary lesion severity.2.MPVLR and PLR are independent risk factors for predicting the severity of coronary artery disease in patients with ACS and T2 DM,but MPVLR is superior to PLR in judging the severity of coronary lesions in patients with ACS and T2 DM.