Spray Freeze-dried Preparation For Injection Danshen

Danshen is Labiatae Salvia Salvia miltiorrhiza Bge.Dried roots and rhizomes.In traditional Chinese medicine,medicine Salvia is blood circulation in the long-term application of modern clinical basis,is a common drug used to treat angina,coronary heart disease,stroke and other diseases.TCM injections in the clinical treatment has shown a very important role,not only to retain the traditional Chinese medicine syndrome differentiation to some-extent this characteristic,and fast-acting,rapid onset,but also play an important role in the treatment of severe crisis.This research Salvia powder for injection,mainly used in clinical Huoxuetongmai For Chest stasis,chest tingling,palpitations,angina pectoris can be used.This paper uses a spray freeze drying method for injection salvia,just around the corner does not affect the active ingredients of the drug,while greatly reducing the duration of the drying process.In this paper,extraction and purification processes,injection molding process and quality standards Salvia powder injection were studied experimentally.Orthogonal experiment method to Danshensu sodium content and dry extract yield of the indexes studied Salvia extraction and purification process;in bulk density and angle of repose of the indexes studied molding process;conducted Salvia and qualitative identification and danshensu protocatechualdehyde HPLC determination.As a result,the amount of Salvia 8 times 75%ethanol was extracted three times,each time after 2.5 hours,filtered,the combined filtrates were concentrated to the relative density of the liquid 1.08,diluted with water six times to stand for 12 hours,filtered,the combined filtrates were concentrated and ethanol containing alcohol amounted to 75%,after the liquid was allowed to stand and concentrated to the relative density 1.08,6-fold diluted with water after 12 hours,after filtration,the combined filtrate was concentrated to a liquid the relative density of 1.10,the material temperature was lowered to-35?,feed speed of the peristaltic pump 80,and dried for 8 hours spray freeze-drying.In the study of quality standards,the TLC qualitative identification results for the test at the same location the reference was the same color spots and negative control without interference;danshensu and protocatechuic aldehyde content to meet the requirements.