| Sildenafil is a piperazine derivative,for the first time in the United States in 1998,it citrate is FDA approved the first oral drug for the treatment of sexual dysfunction,trade name Viagra,Chinese translation as Viagra,is a cyclic guanosine monophosphate(cGMP)-specific phosphodiesterase type 5(PDE5)selective inhibitor,has been widely used in clinical practice,the main purposes are:the body can enhance erectile response,treatment of men do not infertility and impotence,female sexual dysfunction and cardiovascular disease.In this study,the determination of sildenafil citrate dissolution dropping pills of different prescriptions,select dissolution dropping pills prescription better pharmacokinetic experiments.Nitially identified seven types of prescription Sildenafil Citrate drop pills on the basis of the literature and pre-experiment,select PEG4000 and PEG1500 matrix,roundness inspection pass rate of seven prescription dropping pills,pills hardness,yield,the dissolution of the case,to select the best dissolution Pill pharmacokinetic experiments.DSC and TEM analysis showed the presence of sildenafil in the amorphous matrix,forming a solid dispersion.Using the " Chinese Pharmacopoeia" 2010 edition of Appendix XC,the first method)to 900ml 0.1 M hydrochloric acid solution as the dissolution medium,the temperature is 37℃,speed of 100rpm,sampling within the prescribed time points,and get a peak by HPLC area,the drug concentration is calculated according to a standard curve obtained by cumulative dissolution.Preparation of seven kinds of prescription drop pills each group,respectively,with determination and dissolution testing,drug content visit the main drop pills meets experimental standard,uniformity of dissolution eligibility.By comparing the pharmacokinetics of a commercially available tablet dissolution and,preferably selected dissolution experiments prescription PillSignificant difference in Dripping Pills group and large group rodenticide materials showed a pharmacokinetic parameters of sildenafil citrate adding accessories to drop pills in pharmacokinetics in rats had a significant impact.Half-life group was dropping pills t1/2=0.511,the half-life of bulk drugs group t1/2=1.333,described the drug elimination rate difference,adding accessories to change the rate of elimination of sildenafil citrate,also confirmed the accessories can be changed to eliminate the speed they added this drug.Absorption rate constant dripping pill group,Ka=2.411,bulk drugs group Ka=1.221,explains the advantages of drop pills preparation group,the absorption rate after adding accessories specific absorption rate did not increase when materials faster.AUC(0-t)values drop pills group was 74.888,bulk drugs group was 6.694,three sets of data can be seen from their drug area under the curve order:Dripping Pills group>bulk drugs group,indicating bulk drugs in the drug group the absorption amount is less than the absorption Pill group.By comparing the pharmacokinetic parameters,reflecting the advantages of Dripping Pills Sildenafil Citrate dropping pills. |
