Relationship Between Clinical Characteristics And PFS In Young Colorectal Cancer Patients

ObjectiveThis article aims to analyze the clinical characteristics of young colorectal cancerans and provide the basis for clinical diagnosis,treatment and judging the prognosis.The relationship between sex,age,family history of cancer,BMI,weight loss,hemoglobin,platelet count,CA19-9,radical surgery,tumor location,pathological type,TNM stage,postoperative chemotherapy cycles and progression-free survival was investigate by statistical software.MethodThe clinical data of colorectal cancer patients under the age of 44 were collected from January 2010 to June 2012 in Liaoning cancer hospital.The patients of the study were screened from the collected cases with complete clinical features and follow-up data.Data analysis was performed using SPSS 17.0 statistical software.The progression free survival was observed indicators.Analyzing the relationship between sex,age,family history of cancer,BMI,weight loss,hemoglobin,platelet count,CA19-9,radical surgery,tumor location,pathological type,TNM stage,postoperative chemotherapy cycles and progression-free survival by Kaplan-Meier method(P<0.05).The survival curves were compared by Log-Rank test.According to the single factor analysis results,multivariate analysis was performed by the COX model,and analysis of which were independent risk factors for progression-free survival in young colorectal cancer patients.Results1.Single factor analysis showed: Progression-free survival was associated with BMI at diagnosis(?2=9.821,P=0.007),weight loss(?2=4.746,P=0.029),radical surgery(?2=17.354,P=0.000),tumor location(?2=8.485,P=0.014),TNM stage(?2=8.732,P=0.013)(Table1).The family history of cancer has nothing to do withPFS(?2=3.616,P=0.057),But the P value is very close to 0.05,there is a tendency for cancer family history to have a shorter PFS.2.Multivariate analysis by the COX model showed: BMI,the type of surgery the independent risk factors for progression-free survival in young colorectal cancer patients.Conclusions1.BMI at diagnosis,weight loss,radical surgery,tumor location,TNM stage are associated with PFS.Sex,age,family history of cancer,hemoglobin,platelet count,CA19-9,pathological type,,postoperative chemotherapy cycles were not associated with progression-free survival.(Table1)2.BMI,the type of surgery the independent risk factors for progression-free survival in young colorectal cancer patients.