The Clinical Study On The Retinal Change Of Parkinson's Disease

background: Parkinson's disease(PD)is a common neurodegenerative disease in the elderly,showing the typical motor symptoms and some nonmotor symptoms,during which visual function damage caused by the retinal change is also common in PD patients.Objective: this study was to evaluate PD patients retinal nerve fiber layer thickness(RNFLT)and central macular thickness(CMT)by optical coherence tomography(OCT),and to explore the relationship between retinal change and clinical characteristics of the PD patients.Methods: It was from November 2015 to February 2017 in the Department of Neurology,the First Affiliated Hospital of Dalian Medical University to choose33 confirmed PD patients(66 eyes)and 20 healthy subjects as controls(40 eyes)into the study,using OCT to detect all the subjects to draw relevant parameters,namely each quadrant RNFLT,average RNFLT and CMT,at the same time,to analysis PD subgroups,which including: gender(male: female),the degree of motor symtoms(left,right),subtype(tremor group: rigidity group),the beginning side(left,right),treatment(used: first diagnosis),SWI(abnormal: normal)and P300(abnormal:normal).Finally using SPSS23.0 statistical software to analyze the data from two groups of subjects,with p < 0.05 for the difference was statistically significant.Results:(1)In PD group and the controls,the each quadrant RNFLT,bilateral average RNFLT and CMT were no significant differences(P>0.05).(2)In PD group,there was no significant differences between the right eyes and the left onCMT(P>0.05),and the CMT was not relevant with the course of disease,onset age,H&Y stages and UPDRS score.In the subgroup analysis of PD patients,there was no significant difference during gender,beginning side of disease,PD subtypes,the degree of motor symtoms and P300 test results(P>0.05).But compared with less medication patients,treatment patients left eye CMT was thinner(P=0.042),which was associated with more patient starting on the left side during the treatment patient.In the patients with SWI prompting low signal,the bilateral eyes of CMT were thinner(P<0.05).(3)In PD patients,the right temporal RNFLT has a significant positive correlation with the duration of disease;there was a significant positive correlation between the right nasal side RNFLT and H&Y stages,UPDRS-III score.In the subgroup analysis of PD patients,there was no significant difference during gender,beginning side of disease,PD subtypes,the degree of motor symtoms and P300 test results(P>0.05).But compared with less medication patients,right temporal RNFLT of treatment patients was thickened(P=0.008).(4)In PD group,there was no significant differences between the right eyes and the left on average RNFLT(P<0.05),and the average RNFLT were not relevant with the duration of disease,H&Y stages and UPDRS score,but average RNFLT of the left eye was negatively correlated with age,and each average RNFLT was negatively correlated with onset age.In the subgroup analysis of PD patients,there was no significant difference during gender,beginning side of disease,PD subtypes,the degree of motor symtoms,P300 test results and the SWI results(P>0.05).But compared with less medication patients,the right average RNFLT of treatment patients thicken(P=0.047).Conclusion: This study between PD patients and the control group did not find any significant differences on the quadrant RNFLT,each average RNFLT and CMT.In PD patients,right nasal RNFLT has a significant positive correlation with the seriousness of the PD.the right average RNFLT negatively correlated with onset age was markedly thickened in the treated patients.And it was the first time found that in PD patients of SWI anomalies the bilateral CMT was thinning.The long-term and further research was needed to show the possibility of remote retinal dopaminedepletion.