| Objective To study differential diagnosis and treatment of the lungs infection of the procalcitonin and high sensitive C reactive protein in the monitoring of severe brain injury.Methods 80patients(The traffic accident in 38 cases,20cases of upper falls,injured in 15 cases,the remaining 7 cases)with severe traumatic brain injury from January 2015 to January 2016 in our hospital were researched.40 cases had pulmonary infection as infection group,the other 40cases were uninfected group.In the uninfected group,the procalcitonin(PCT)was detected in the hospital,and the infection group was confirmed to be infected,In the first day,to detect the level of procalcitonin(PCT)and high sensitive C reactive protein(hs-CRP),Infection group were given the corresponding anti infection treatment,grouping according to the patient’s infection,They were divided into two groups:infection group(24 cases)and infection group(n=16),after infection,3d,7d,the levels of PCT and hs-CRP were detected respectively.Results 1.There was no significant difference in the incidence of pulmonary infection between the patients’age and smoking history(P>0.05);2、At the time of admission to the first day,the levels of PCT and hs-CRP in the infection group were higher than those in the uninfected group[(3.85±0.51)ng/ml比(0.53±0.15)ng/ml,(61.23±17.34)mg/L比(50.12±13.12)mg/L](P<0.05);in the infection group,24 cases were improved,after infection 3d,,the PCT,hs-CRP levels were lower than the confirmedinfectionday{3.78±0.56ng/mland1.78±0.43ng/ml;61.04±17.27mg/L and 45.73±12.91mg/L}(P<0.05}(P<0.05);after infection7d,the PCT,hs-CRP levels were lower than the confirmed infection day{3.78±0.56ng/ml and 0.74±0.21 ng/ml;61.04±17.27mg/L and21.08±5.30mg/L}(P<0.05);the other 16 patients were infected continuously,the PCT and hs-CRP levels were increased continuously at the time of infection,the difference was statistically significant between the day and theconfirmedinfection{3.81±0.52ng/mland7.34±1.93~*ng/ml;61.16±17.26mg/Land109.78±17.21~*mg/L3.81±0.52ng/mland7.03±1.87ng/ml;61.16±17.26mg/L and 107.45±15.74~*mg/L}(P<0.05).Conclusion 1,history of smoking and drinking on the rate had no significant effect on the patients with severe brain damage factors of pulmonary infection,2,PCT as a kind of infection is highly sensitive and specific indexes,the advent of the date from which it was gradually applied and Department of Cardiology,Department of rheumatism,Department of infectious diseases,in recent years,the application in the Department of Neurosurgery gradually to be developed,procalcitonin and hs-CRP because of its detection in severe craniocerebral injury with high specificity sensitivity in patients with pulmonary infection,it can be used for the early evaluation of diagnosis index of pulmonary infection in patients with severe craniocerebral injury.3,procalcitonin and high sensitivity C reactive protein in the infection group improved after anti infection treatment after concentration decreased gradually,and the infection of clinical symptoms and effects were also gradually improved,that of procalcitonin and high sensitive C reactive protein and can be used to guide the clinical application of antibiotics,can control the situation assessment the efficacy of antibiotics effective evaluation and infection,and reduce the hospitalization time and hospitalization expenses,provided some help to reduce the overuse of antibiotics for clinical rational use of antibiotics.The concentration of procalcitonin and high sensitive C reactive protein in the infected group continued to increase,combined with clinical manifestations,it can be concluded that the concentration of procalcitonin was positively correlated with the severity of infection.This gives us the clinicians at work and provides a diagnosis of infection site of infection in a patient with the severity of the new index,because the procalcitonin is convenient,compared with the CT imaging of lower prices,for our convenience clinicians did not reduce the hospitalization expenses of patients. |
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