The Preliminary Study Of The High-density Lipoprotein(HDL-C) Changes On Myocarditis And Possible Mechanism

[Objective]Myocarditis is an inflammatory heart disease that poses many risks to humans.It is progressive,can cause severe heart failure,arrhythmia,shock,and death.The pathogenesis of myocarditis is not clear now and there is no specific treatment for myocarditis.Dyslipidemia plays an important role in the pathogenesis of atherosclerosis and other cardiovascular disease.However,rare research pay attention to dyslipidemia in myocarditis.We make a preliminary study on the dyslipidemia in myocarditis,and analyze the correlation between lipids and myocarditis.In order to find a new way for the diagnosis and treatment of myocarditis[Methods]In clinical experiments,,we examined basic information included myocardial damage markers CK-MB/cTnT levels,heart function index BNP,echocardiographic index,and blood lipids of 110 myocarditis patients in Xiamen cardiovascular hospital Xiamen university.Then examined 15-inflammation cytokinesof plasma with Bio-Plex Suspension Array System.In animal experiments,we making EAM model,then analysis of lipid levels in animal models.Found out lipid levels of rats changed as myocarditis patients.What’s more,improve of HDL level improves cardiac functions in rats.Inflammatory factors,myocardial injury factors,fibrosis factors also improved in EAM rats.[Results]Compared with control group,myocarditis group showed increased of inflammation,myocardial injury markers CK-MB/cTnT and cardiac function indexes BNP.The entireechocardiographic index worse than the control group.Lipid levels also have changed,mainly HDL decreased.Further analysis found out that HDL significantly lower than myocarditis group,and have linear correlation with cTNT.The lower HDL levels,the higher cTNT levels.Animal experiments show the same situation in EAM rats.HDL lower than control group.Increase of HDL after treatment with fenofibrate,inflammation,myocardial damage,and myocardial fibrosis index improved significantly.[Conclusion]HDL decreased significantly in patients with myocarditis as well as the increase of inflammation.The HDL have linear correlation with myocardial injury markers cTNT.HDL have a protective role in myocarditis,raise HDL can be reduce myocardial injury.This research improve the prognosis of myocarditis and a potential therapeutic target.