Meta-analysis On The Clinical Effects Of Benefiting Qi And Activating Blood Circulation In The Treatment Of Middle And Senile Hypertension

Objective The purpose of this meta-analysis was to assess the efficacy of formula benefiting qi and activating blood circulation with or without western medicine in the treatment of middle and senile hypertension.Methods Base on into and exclusion criteria,computer search cooperate with manual retrieval has been applied to collect related literature.Five databases included CNKI,CMB,VIP,Wan-fang and Pub Med were searched up to October 2016.Controlled trials comparing formula benefiting qi and activating blood circulation with or without western medicine(treatment group)with western medicine alone(control group)for the treatment of middle and senile hypertension were analyzed.Twenty-four studies were included in this review.The relevant information of included RCTs was gathered.Rev Man 5.3 offered by the Cochrane was used to do the Meta analysis.Result Twenty-four studies,comprising formula benefiting qi and activating blood circulation alone six studies and formula benefiting qi and activating blood circulation with western medicine eighteen studies,were included in this review.Meta-analysis results show that: Compared with western medicine,the formula benefiting qi and activating blood circulation shows that the differences of antihypertensive effects in two groups have no statistical significance(P=0.62),but with statistical significance in cholesterol lowering(P=0.006)and improve blood flow dynamics(P <0.00001).The western medicine combine with the benefiting qi and activating blood circulation TCM compare with western medicine alone shows that the treatment group shows more benefit compare with the control group and the differences were with statistically significant.These advantages embodied in antihypertensive effects(P<0.00001),to improve the Symptoms of TCM(P<0.00001),total cholesterol lowering(P=0.001),reduction of triglycerides(P=0.009),reduction of LDL cholesterol(P=0.0005),the improvement of whole blood viscosity(P<0.00001),plasma viscosity(P<0.00001)and fibrinogen(P=0.03),reduction of Hcy(P=0.003)and so on.Conclusions The method of benefiting qi and activating blood circulation shows a definite effect in the treatment of middle and senile hypertension.TCM of benefiting qi and activating blood circulation combine with western medicine is more favorable to antihypertensive,lipid regulation and improve blood flow dynamics,which is without adding to the adverse reactions,worth clinical promotion.Because the most of included studies which with heterogeneity and the uncertainty of risk of bias are low quality,so the credibility of conclusions is open to doubt.I hope the higher quality RCT join us to certify the conclusions in future.