Pathological Analysis Of Multifocal Breast Cancer

Objective To compare the clinical and pathological features of multifocal breast cancer lesions.Methods A retrospective analysis was made covering 41 multifocal breast cancer cases treated in our research team since 2014;Conventional histopathological and immunohistochemical detection results between different lesions and their molecular subtypes were compared.A total of 150 cases of unifocal breast cancer in the same period were selected into the control group.Lesion size,nuclear grade,lymph node status and intravascular tumor thrombus of the two groups were compared.Results Among 41 patients,32 were detected with 2 lesions,8 with 3 lesions,1 with 4 lesions;T? 2cm appeared in 18 cases,2cm<T?5cm in 22 cases,and T>5cm in 1 case.There were 24 cases of lymph node metastasis,12 cases of intravascular tumor thrombus,33 cases had the same pathological features in different lesions.The same level of ER,PR,Her-2 and Ki-67 appeared in 38 cases(93%),35 cases(85%),37 cases(90%)and 38 cases(93%)respectively.36(88%)cases had the same molecular subtypes.There were significant differences in nuclear grade,lymph node metastasis and intravascular tumor thrombus(P<0.05),and the lesion size had no significant difference(P>0.05)between breast cancer with multiple lesions and breast cancer with single lesion.Conclusion Clinicopathological results may vary in the lesions of multifocal breast cancer.Therefore,routine pathological and immunohistochemical examination should be carried out in all lesions so as to provide accurate and comprehensive diagnostic evidence.For multifocal breast cancer that is more likely to attack high nuclear grade patients,lymph node metastasis and intravascular tumor thrombus are all common occurrences,suggesting that patients have poor prognosis.