Studies On Expression Levels And Correlation Of Peripheral Serum SFas And SLOX-1 In Patients With Acute Coronary Syndrome

Objective:To detect the expression levels of peripheral serum sFas and sLOX-1 in patients with acute coronary syndrome(ACS),analyze the correlations between they and the number of coronary artery lesions,the degree of coronary artery stenosis(using Gensini score as evaluation criteria),CK-MB and cTnI,as well as between themselves,and investigate the function and clinical diagnostic value during the occurrence and development of ACS.Methods:A total of 52 patients definitely diagnosed with ACS(ACS group)by coronary artery angiography(CAG)were enrolled,including 23 cases of unstable angina(UA group)and 29 cases of acute myocardial infarction(AMI group),and according to angiography findings,further divided into 16 cases of single coronary artery stenosis group,14 cases of two coronary arteries stenosis group and 22 cases of multi coronary arteries stenosis group,and contemporaneous 58 cases non-coronary artery stenosis confirmed by CAG were selected as the control group(NC group).To record all selected objects in general,including age,sex,history of hypertension,diabetes and smoking and so on.The levels of sFas and sLOX-1 were measured by enzyme linked immunosorbent assay(ELISA),and the levels of CK-MB and cTnI were detected by an automatic biochemical analyzer.Results:(1)Compared with the NC group,the levels of peripheral serum sFas and sLOX-1 in the ACS group were increased observably(388.195 ± 119.739 ng/L VS 159.835 ± 75.705 ng/L,1578.564 ± 477.863 ng/L VS 385.273 ± 300.892 ng/L,all P<0.01),the levels of peripheral serum sFas and sLOX-1 in the AMI group and UA group were higher than those in the NC group,moreover which in the AMI group were higher than those in the UA group(421.307 ± 132.979 ng/L VS 346.445 ± 86.380 ng/L VS 159.835 ± 75.705 ng/L,1755.262 ± 513.581 ng/L VS 1355.770 ± 317.194 ng/L VS 385.273 ± 300.892 ng/L,all P<0.01);(2)Compared with the NC group,the levels of peripheral serum sFas and sLOX-1were higher in single coronary artery stenosis group,two coronary arteries stenosis group and multi coronary arteries stenosis group(all P<0.05),and One-way ANOVA shows that there were statistic differences among single coronary artery stenosis group,two coronary arteries stenosis group and multi coronary arteries stenosis group(337.717 ± 112.838 ng/L VS 362.695 ± 133.799 ng/L VS 383.951 ± 136.420 ng/L,1333.480 ± 587.488 ng/L VS 1359.624 ± 589.657 ng/L VS 1431.622 ± 642.985 ng/L,P<0.05);(3)The peripheral serum sFas level in the ACS group was positively correlated with the peripheral serum sFas level(r=0.825,P=0.001);(4)The levels of peripheral serum sFas and sLOX-1 in the ACS group were all positively correlated with Gensini(r=0.802,P=0.001 and r=0.906,P=0.001),but both had no obvious correlation with serum levels of CK-MB(r =0.098,P=0.425 and r=0.134,P=0.274)and cTnI(r=0.129,P=0.357 and r=0.235,P=0.090).Conclusion:High levels of sFas and sLOX-1 in the peripheral serum may be the risk factors of ACS,both may had a positive interaction with each other in contributing to the occurrence,development and rupture of atherosclerotic plaque of ACS through the mechanism of cell apoptosis and inflammatory response,and their joint detection can better reflect the degree of plaque instability and the severity of ACS,to provide a new reference for diagnosis,treatment and prognosis of ACS.