Effect Of Acupuncture-Rehabilitation On The Motor Function Of Upper Extremities And Serum BDNF And VEGF In Patients With Cerebral Infarction

Objectives:To explore the effect of Acupuncture-rehabilitationon the upper limbs motor dysfunction and serum BDNF and VEGF in patients with cerebral infarction,and to find serum markers that can reflect the clinical efficacy of Acupuncture-rehabilitationon.Methods:Patients with upper extremity motor dysfunction who were meet diagnostics and inclusion criteria in the cerebral infarction were divided into three groups:30 in Acupuncture-rehabilitation group,acupuncture group 30 people,rehabilitation group 30,a total of 90 cases.The Modified Barthel Index(MBI),Fugl-Meyer Upper limb Asses(U-FMA)and Wolf Motor Function Test(WMFT)were used evaluated the therapeutic efficacy before the first treatment and on the first day after the treatment.At the same time,the changes of serum BDNF and VEGF levels in three groups at the time of admission and on the last day of treatment were detected.Results:1.Before treatment,the Acupuncture-rehabilitation group,the acupuncture group and rehabilitation group in the U-FMA score,WMFT score,MBI score,serum BDNF and VEGF content the difference was not statistically significant(P>0.05),comparable.2.After treatment,the U-FMA score,WMFT score,the MBI score,the serum BDNF and VEGF levels in the upper limbs of the three groups were all higher than before treatment,and the difference was statistically significant(P<0.05);3.After treatment,the Acupuncture-rehabilitation group had better improvement in the improvement of U-FMA score,WMFT score,MBI score,serum BDNF and VEGF in the upper extremity than in the acupuncture group and the rehabilitation group(P<0.05).4.After the Acupuncture-rehabilitation treatment,there was a positive correlation between "increased BDNF content" and "the elevation value of U-FMA score and WMFT score and MBI score"(r = 0.113,P<0.05);(r =0.363,P<0.05);r=0.185,P<0.05),the difference was statistically significant;5.After the Acupuncture-rehabilitation treatment,there was a positive correlation between "increased VEGF content" and the elevation value of U-FMA score and WMFT score and MBI score"(r =0.122,P<0.05);(r=0.406,P<0.05);(r=0.1 93,P<0.05),the difference was statistically significant;Conclusions:1.The Acupuncture-rehabilitationcan improve U-FMA score,WMFT score,MBI score,serum BDNF and VEGF in patients with upper limb dysfunction after cerebral infarction.2.Serum BDNF and VEGF can be used as serum markers for treatment of upper extremity motor dysfunction after cerebral infarction.