Clinical Analysis Of 378 Case Thymoma

Objective:To analysis the clinical characteristics of thymoma and discuss clinical staging,pathological type,treatment methods and influence factors.Methods:Statistical analysis of 378 patients with thymoma that were treated in my hospital from January 1985 to November 2012,and our experienced pathology doctor to old pathological types according to the WHO classification(2004)classification,follow-up of 239 patients,the survival rate calculation and the single factor of survival analysis using Kaplan Meier method,meanwhile differences in using the Log-rank test to calculate.All live via single factor analysis of meaningful parameters into the multi-factors Cox regression model to calculate the survival analysis,the related factors affecting the prognosis were retrospectively analyzed.Results:The WHO statistics found that the thymus tumor credits type and have a high correlation between pathological Masaoka staging(P<0.01).Follow-up of 239 patients,single factor analysis showed:age,clinical symptoms,tumor resection range or not,whether infringement of great vessels,WHO histological classification,Masaoka stage has a significant influence on the prognosis of patients with thymoma.Scope of Cox model,multi-factor analysis showed that tumor resection,whether infringement of great vessels,the WHO classification,Masaoka staging is the independent factors affecting long-term survival in patients with thymic tumor.Whether merger can not influence the prognosis of myasthenia gravis with thymoma.?-? period patients with thymoma resection + radiotherapy/chemotherapy,the prognosis of patients with preoperative radiotherapy/chemotherapy plus surgery is good,but put/neoadjuvant preoperative chemotherapy failed to improve the prognosis of patients,but can make tumor shrinkage,reduce blood vessels,mediastinal invasion and improve operation complete resection.Conclusion:Surgery is the treatment of choice for thymoma,of clinically suspected thymoma,except for clinical examination proved unable to tumor resection or distant metastasis should be surgical treatment as soon as possible,in order to get better long-dated curative effect of complete resection of the tumor,according to the specific circumstances given postoperative radiotherapy,chemotherapy or combined radiation and chemotherapy.Preoperative chemotherapy put/failed to improving the prognosis of patients with ? period,but can make tumor shrinkage,reduce blood vessels,mediastinal invasion,improve operation complete resection.Multi-factor analysis showed that the WHO classification,Masaoka stage,tumor resection scope,whether infringement of large blood vessels are the independent factors affecting the prognosis of patients with thymoma.