Analysis On The Relationships Among The Pathology Classification, Masaoka Clinical Stages Of Thymoma And Myasthenia Gravis, Myasthenia Gravis Crisis

Objective: To investigate the relationships among the pathologyclassification,Masaoka clinical stages of thymoma and myasthenia gravis,myastheniagravis crisis. In order to provide help for clinical diagnosis and treatment.Methods: We retrospectively studied the pathological sections and clinical data of123thymoma patients who had surgically treated in the Department of ThoracicSurgery of the First Affiliated of Fujian Medical University from Dec.2004toDec.2013.We used the WHO classification standard(2004) to classify the thymoma.Using the SPSS for Windows19.0,we analyse the relationships among the pathologyclassification,Masaoka clinical stages of thymoma and myasthenia gravis,myastheniagravis crisis.Results:①The pathological examination demonstrated12cases of type A,38casesof type AB,16cases of type B1,29cases of type B2,25cases of type B3,3cases ofthymic carcinoma from which58cases are myasthenia gravis patients. The pathologyclassification of thymoma is significantly correlated to the occurrence of myastheniagravis （P＜0.05）. Furthermore, type B is much more likely to be accompanied bymyasthenia gravis.②58cases are myasthenia gravis patients including27cases instage Ⅰ,18cases in stage Ⅱ,8cases in stage Ⅲ,5cases in stage Ⅳ. Another65cases are not myasthenia gravis patients including11cases in stage Ⅰ,23cases instage Ⅱ,25cases in stage Ⅲ,6cases in stage Ⅳ. The Masaoka clinical stages ofthymoma is significantly correlated with the occurrence of myasthenia gravis（P＜0.05）. Thymoma with myasthenia gravis has earlier stage than thymomawithout myasthenia gravis.③We found12cases occurre in Myasthenia gravis crisis.The pathology classification of thymoma is not correlated with the occurrence ofmyasthenia gravis crisis（P＞0.05）.But the Masaoka clinical stages and malignantdegree of thymoma is significantly correlated with the occurrence of myasthenia gravis crisis（P＜0.05）. The myasthenia gravis crisis is more likely to happen inmalignant thymoma.Conclusion:1.The WHO classification (2004) is significantly correlated with the occurrence ofmyasthenia gravis. Type B is much more likely to be accompanied by myastheniagravis. Before the operation we must pay attention to check whether patients withmyasthenia gravis.2. The occurrence of myasthenia gravis is significantly correlated with the Masaokaclinical stages of thymoma. Because of the obvious symptoms, Thymomawith myasthenia gravis may be found earlier and may has earlier stage.3. The WHO classification (2004) is not correlated with the occurrence of myastheniagravis crisis.4.The Masaoka clinical stage of thymoma is significantly correlated with theoccurrence of myasthenia gravis crisis. The later stage means that tumor invasion maybe larger,the involvement degree of nerve may be heavier, tumor micrometastasespossibility is larger and tumor resection may not clean which may lead to themyasthenia gravis crisis.For the thymoma we must pay more attention to preventoccurrence of myasthenia gravis crisis. We should try our best to find the threatenedof myasthenia gravis crisis and give active treatment.5.The WHO(2004) pathology classification and the Masaoka clinical stages ofthymoma can provide help for clinical diagnosis and treatment. It also has guidingsignificance in preventing occurrence of myasthenia gravis crisis.