Alterations Of Dementia With Lewy Body And Parkinson's Disease:a Multimodal Resting-state Functional Magnetic Resonance Imaging Study

Part?:Abnormal changes of cortical gray matter volume in dementia with Lewy body and Parkinson's diseaseObjective:To investigate brain changes of gray volume between dementia with Lewy body and Parkinson's diseaseMethods:A total of 16 patients with dementia with Lewy body patients,20 patients with Parkinson's disease patients and 20 well-matched healthy controls were scanned with T1 structure magnetic resonance imaging.The difference of gray matter volume(GMV)between three groups was analyzed by using the method of voxel-based morphology(VBM).The Mini Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA)and Unified Parkinson's Disease Rating Scale-?(UPDRS-?)were performed to assess the neuropsychological symptomsResults:There were significant differences of total gray matter volumetric among the three groups by one-way analysis of variance(ANOVA).Further Post hoc analyses showed that the DLB patients showed reduced gray matter volume in bilateral temporal lobe,bilateral caudate nucleus,left cerebellum anterior lobe as compared with the controls.When Compared with the PD patients,the DLB patients showed decreased gray matter volume in right caudate,right temporal lobeConclusion:The changes of GMV suggest that the structures of multiple brain regions in DLB group were changed,which provided a new method to explore the pathological mechanism and diagnosis of DLB and PD.The change of caudate nuclear structure can be helpful for the differential diagnosis between DLB and PD.Part?:The study on resting-state regional homogeneity in patients with dementia with Lewy body and Parkinson's diseaseObjective:To investigate the change of regional homogeneity(ReHo)and its relationship with the severity of clinical symptoms in dementia with Lewy body and Parkinson's disease patients.Methods:A total of 16 dementia with Lewy body(DLB)patients,20 Parkinson's disease(PD)patients and 20 well-matched healthy controls were scanned with rs-fMRI for ReHo analysis.The Mini Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA)and Unified Parkinson's disease rating scale-?(UPDRS-?)were assessed,and the relationships between the changes of ReHo values and severity of clinical symptoms were performed.Results:The one-way ANOVA of total brain ReHo values in the three groups showed significant group effect.After comparison,it was found that compared with the control group,the ReHo values were increased in the anterior lobe of left cerebellum,and ReHo values were reduced in left frontal gyrus;the back of the left occipital,the bilateral caudate nucleus,while ReHo values were increased in the right superior temporal gyrus and right supramarginal gyrus in PD group.Compared with the PD group,DLB group had an increased ReHo values in bilateral caudate nucleus and decreased in right supramarginal gyrus.There was significantly negative correlation between ReHo values of bilateral caudate nucleus and the UPDRS-?score in DLB group.Conclusion:There were abnormal ReHo activities in patients with DLB and PD,Further,there was a difference between two groups,which may be related to disease's physiopathologic mechanism.