| Objective: Gastrointestinal neuroendocrine tumor is rare and atypical,and it is often found in the middle and late stage,so we need to investigate the clinical characteristic of GI-NET,and strengthen the understanding of this disease,and reduce the misdiagnosis rate.Methods:the clinical data of 60 patients with gastrointestinal neuroendocrine tumor were collected and treated in the XXXX medical university from 2004 to 2017.And the patient's gender,age,tumor location,the main clinical manifestations,endoscopic performance,tumor size,diameter of pathological grading,immunohistochemical index Syn and Cg A positive rate,treatment and tumor lymph node metastasis and distant metastasis,and tumor location,diameter size and the relationship of the postoperative pathological classification and so on carries on the statistical analysis.Statistical: methods SPSS 22.0 statistical software package was used for data analysis.Compared using the chi-squared line × list data.The test level is0.05.Results: the incidence of gastrointestinal neuroendocrine tumor increased year by year,2004,2009,2010,2009 each have 1,4 cases in 2013,11 cases in 2014,10 cases in 2015,13 cases in 2016 and 18 cases in 2017.Among the60 patients with gastrointestinal neuroendocrine tumor,aged between 29 and88,the median age was 57 years old,and the number of patients agedbetween 51 and 70 was more than 60 percent.The tumor was located in the rectum at most 42 cases(70%),followed by 5 cases in the stomach(10%),4cases(6.7%)in the colon and duodenum,and 3 cases(5%)and 2 cases(3.3%)respectively.None of the 60 patients had atypical carcinoid syndrome,and only 8 had diarrhea in the intestinal tract.There were 40 cases of tumor diameter with a diameter of 1cm and 66.7%(40/60).The tumor diameter was between 1 and 2cm,with 5 cases(5/60),and the tumor diameter was 2cm in15 cases,accounting for 25%(15/60).The tumor diameter of the stomach and rectum was more than 1cm,and the number of tumors in the blind,jejunum and colon regions was more than 2cm,and the difference was statistically significant(P<0.001).The 60 cases of GI-NET are both located in submucosa,Among them,51 cases were able to be pushed,accounting for 85%,and nine cases could not be pushed,accounting for 15%.The color description of the tumor:38 cases are gray-white(63.3%),14 cases are light-yellow(23.3%),gray-red,dark-red are 8 cases(13.3%);The texture description of tumor: the49 cases were characterized by texture,accounting for 81.7%,7 cases were characterized by toughness,accounting for 11.7%,4 cases were of medium quality,accounting for 6.6%;Describe the tumor surface:The 41 cases showed smooth surface(68.3%),10 cases showed rough surface(16.7%),9cases showed erosion surface(15%).There were 41 cases(78.8%),4 cases(7.7%),and 7 cases(13.5%)in G3 level.The pathological grading of GI-NET was mostly G1,and the pathological grading was related to the site of the tumor.The difference was statistically significant(P<0.001).Gastrointestinal neuroendocrine tumor,Syn(synapse)detection positive rate was 98.1%(51/52),Cg A(chromogranin A,chromaffin grain protein A)detection positive rate was 55.8%(29/52),the difference between the two was statistically significant(P < 0.001).There was no statistical significance(P=0.994)in the detection of positive rate of Syn in the tumors of various parts of the gastrointestinal tract,and there was statistical significance(P=0.013)for CgA detection of positive rate.To the endoscopic treatment of 33 cases accounted for 55%(33/60),surgical treatment,18 cases accounted for 30%(18/60),targeted drug treatment,2 cases accounted for 3.3%(2/60),chemical drugs combined surgical treatment,1 case was 1.7%(1/60),only for non-functional symptoms give symptomatic treatment drugs,6 cases accounted for 10%(6/60).There were 7 cases of lymph node dissection in 60 patients,among which there were 4 cases with lymph node metastasis.There were 7 patients with distant metastasis before the operation,4 of them were treated with surgery and cleaned the surrounding lymph nodes at the same time,and 3 of which with lymph node metastasis.The tumor diameter was 2cm,with no lymph node metastasis of G1 and G2 grade.There were statistically significant differences between lymph node metastasis and tumor diameter and pathological grading(P<0.05)and no statistical significance with the location(P>0.05).Patients with tumor diameter of 1cm and grade G1 had no distant metastasis.No distant metastases occurred in rectumboth of the 42.The distant metastasis of the tumor was statistically significant(P<0.05).Conclusions:1.The incidence of GI-NET increased year by year in our hospital,which the age of 51 to 70 years is the most.2.GI-NET is well distributed in the rectum,followed by the stomach especially in the body of the stomach.3.GI-NET lacks specific clinical manifestations and mostly non-fun ctional.4.GI-NET size is more than 1cm in diameter,mainly located in the stomach and rectum.There were more than 2cm of tumors in the blind and colon regions.5.NET is mainly in the mucosa,with gray white,smooth surface and hard texture as the main performance.6.The pathological grading of G1 was relatively large and related to the site of the tumor.The gastric,duodenal and rectal NET were mostly G1,and the tumors in the ileocecus and colon were mostly G3.7.Syn and Cg A test have diagnostic significance,and the sensitivity of Syn is higher than Cg A.The expression difference of Cg A in different location is significant(P<0.05),and the negative rate of Cg A expression in the rectum is 59.0%(23/39).8.GI-NET is still mainly treated with endoscopic therapy and surgical treatment and is related to tumor size and location.9.GI-NET lymph node metastasis was related to diameter and pathology grade(P<0.05),which was not related to the location of tumor(P >0.05).The distant metastasis of tumor was correlated with tumor size,location and pathological grading(P<0.05). 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