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Clinical Observation On The Efficacy Of Niuhuang Shang Qing Capsules On Mild To Medium Degree Acne Vulgaris

Posted on:2019-12-23Degree:MasterType:Thesis
Country:ChinaCandidate:L CaoFull Text:PDF
GTID:2404330548465850Subject:Dermatology
Abstract/Summary:PDF Full Text Request
BackgroundAcne is a sebaceous gland disease characterized by the formation of open and closed acne,papules,pustules,nodules and cysts,which is one of the most common diseases in Department of dermatology.Acne usually occurs between 12-24 years old and is associated with hormones,sebum,hair follicle sediments,bacteria and inflammation.In recent years,the local treatment and systematic treatment of acne have made great progress,such as retinoic acid,antibiotics,laser treatment and so on.However,various treatments usually have different levels of side effects,which damage the compliance of the treatment,and then affect the therapeutic effect.The traditional Chinese medicine theory and the modern pharmaceutical technology of Chinese patent medicine for acne have attracted much attention in recent years because of their mild effects and low side effects.Niuhuang Shang Qing Capsule is based on traditional Chinese medicine for the treatment of heat syndrome.It has the effect of clearing away heat and reducing fire,dispersing wind and alleviating pain,and has a unique anti-inflammatory effect.ObjectiveThe aim of this study is to evaluate the clinical efficacy and safety of Niuhuang Shang Qing capsules in the treatment of mild to medium degree acne vulgaris.MethodsThe 384 cases of patients clinically diagnosed with mild medium degree acne vulgaris were randomly and averagely divided into the therapy group and the control group.The therapy group was treated with Niuhuang Shang Qing capsules combined with clindamycin gel externally.The control group use dg Tanshinone Capsule and clindamycin gel.After 6 weeks treatment course,we observed the changes of acne lesions.The curative effect score and the incidence of adverse reaction were calculated and analyzed.And we further detect ed the physiological status of the skin,including skin water content and oil content.ResultsAfter six weeks,the total effective rate of therapy group and control group were79.2% and 68.6% respectively.And the difference wasn't statistically significant(p>0.05).There were 28 patients with the adverse reactions in the therapy group and 16 patients in the control group.There was no statistically significant difference between the two groups(p>0.05).Finally,after treatment,the skin moisture content of both the treatment group and the control group increased significantly(P <0.01),while the skin oil content decreased significantly(P<0.01).There was no significant difference between the treatment group and the control group in skin moisture content and sebum content(p>0.05).ConclusionFor the treatment of mild to medium degree acne vulgaris,Niuhuang Shang Qing capsules can improve inflammatory and non inflammatory skin lesions in patients.It also has good safety.Thus Niuhuang Shang Qing capsules is worthy of clinical application.
Keywords/Search Tags:Acne, Niuhuang Shang Qing capsules, Tanshinone Capsuleclinda, clindamycin gel
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