The Expression Of MFG-E8 And E-cadherin In NSCLC And Its Significance

Objective: The expression level of MFG-E8 and E-cadherin in lung cancer tissue and para-cancerous tissue of patients with resected NSCLC were detected by immunohistochemical method,and the expression and significance of MFG-E8 and E-cadherin in NSCLC were discussed.Methods: Choose 36 paraffin cases of lung cancer tissue(NSCLC,18 cases of adenocarcinoma and 18 cases of squamous cell carcinoma)were confirmed by pathology,and 18 cases of para-cancerous tissue were selected as control during January 2016 to January 2017 in the First Affiliated Hospital of Hebei North University.The clinical and pathological data were collected.The expression of MFG-E8 and E-cadherin was detected by immunohistochemistry in cancer group and control group,the differential expression of MFG-E8 and E-cadherin of two groups were compared,analysis of MFG-E8 and E-cadherin and their clinical pathological parameters and metastasis correlation,and the correlation between MFG-E8 and E-cadherin.Results :(1)The expression of MFG-E8 in NSCLC tissues was significantly higher than that in para-cancerous tissues(P<0.05).(2)(1)There was no significant difference in MFG-E8 between different age,sex,TNM stage,tissue differentiation and lymph node metastasis(P>0.05).The positive expression rate of adenocarcinoma was higher than that in squamous cell carcinoma(P<0.05).(2)There was no significant difference in E-cadherin between different age,sex,pathological type,tissue differentiation and lymph node metastasis group(P>0.05).There was a difference between TNM stage,and the positive expression rate of the I/II carcinoma tissues was higher than that of stage III(P<0.05).(3)The expression of MFG-E8 and E-cadherin in NSCLC lung cancer tissues is not related(r=-0.310,P>0.05).Conclusion:In this study,thepositive expression rate of MFG-E8 and E-cadherin in NSCLC tissues was higher than that of para-cancerous tissue,indicating that MFG-E8 and E-cadherin were involved in the development of NSCLC,but the expression of two in NSCLC tissues was not related.