The Study On The Treatment Of Premature Ovarian Insufficiency By Hu Yang Yang Kun Recipe

ObjectiveTo observe the clinical effect of Hu Yang Kun Fang recipe on premature ovarian insufficiency(spleen and kidney deficiency syndrome),and provide meaningful clinical evidence for prevention and treatment of this disease by TCM.MethodsWe selected patients from September 2016 to December 2017 in Guangdong Province Traditional Chinese Medical Hospital gynecology screening clinic,or through hospital recruitment advertising.Patients who met the inclusion criteria for premature ovarian insufficiency in early stage of spleen kidney deficiency syndrome were recruited.48 cases were collected and 40 cases were completed.It was a randomized double-blind control study and patients were divided into two groups.Participants in Chinese medicine group were treated by Hu Yang Kun Fang recipe granule combined with DHEA capsule placebo.Patients in the control group were given Chinese medicine granule placebo plus DHEA capsule.The treatment period was 12 weeks.Blood serum was extracted from peripheral venous blood before and after treatment,including serum follicle stimulating hormone,estradiol and anti Mullerian hormone.The most recent menstrual time and menopausal symptom scale were recorded before treatment,4 weeks,8 weeks and 12 weeks after treatment.At the same time,we observed menstrual change and filled in case observation form.The menstrual condition,serum endocrine level and menopausal symptom scores were analyzed before and after treatment.SPSS19.0 statistical software was used to establish data base for data collection and analysis.Results1.Menstrual recovery times: there was no significant difference in menstrual recovery between all patients during treatment(P>0.05).There was no significant difference in the number of menstrual recovery between the two groups(26 cases)with oligomenorrhea(P>0.05).2.The level of menstruation and the overall efficiency: there was no significant difference between the two groups(P>0.05)in the level of menstruation and the total effective rate of the oligomenorrhea patients.After treatment,the menstrual status in the Chinese medicine group was 1.69±0.855 and the total effective rate was 92.3%.The menstrual status in group DHEA was 1.08±0.954 and the total effective rate was 69.2%.3.Comparison of serum endocrine level before and after treatment: Traditional Chinese medicine treatment can reduce the level of serum FSH and increase serum E2 and AMH levels.There is a significant difference in serum E2 level before and after treatment(P<0.05),and there is no significant difference in serum FSH and AMH levels(P>0.05).There was no significant difference in serum FSH,E2 and AMH levels in group DHEA before and after treatment(P>0.05).There was no significant difference in the difference between the two groups in FSH,E2 and AMH before and after treatment(P>0.05).4.The score of the MRS: there was no significant difference between the scores of the total score of the MRS,the psychological dimension,the somato-vegetative dimension and the urogenital dimension in the two groups of different nodes(P>0.05).There was a significant difference in the total score,psychological and urogenital dimension of the MRS before and after the treatment in the Chinese medicine group(P<0.05),and there was no statistical difference between the MRS and the somato-vegetative dimension score group(P > 0.05).There was no significant difference in the total and three dimensions scores of MRS before and after treatment in DHEA group(P>0.05).The total score and somato-vegetative dimension score of the Chinese medicine group decreased significantly after 8 weeks of treatment(P<0.05).The total score,psychological,somato-vegetative and urogenital dimensions of other observation nodes were not significantly lower than those before treatment(P>0.05).The scores of total score,psychological,somato-vegetative and urogenital dimensions of group DHEA at any time after treatment were not significantly decreased compared with those before treatment.Conclusion1.The effect of protecting Hu Yang Yang Kun recipe on the menstrual recovery of women with premature ovarian insufficiency in the early stage of spleen and kidney insufficiency is considerable.2.The Hu Yang Yang Kun recipe can improve the serum level of high FSH and low E2 in patients with premature ovarian insufficiency,and increase serum AMH level.3.The Hu Yang Yang Kun recipe can effectively improve the symptoms of menopause related symptoms of premature ovarian insufficiency,especially the psychological and urogenital symptoms.