| Objects:To explore the effective treatment for patients with advanced NSCLC and the application of traditional Chinese medicine in improving the toxic side effects of chemotherapy process.Methods:A randomized controlled method was used in the study to observe the therapeutic effect of the Huayu Jiedu method for treating advanced NSCLC based on the phlegm and blood stasis syndrome.According to the diagnosis standard of advanced NSCLC for modern medicine,and the phlegm and blood stasis syndrome of Chinese medicine,60 patients with lung cancer were randomly divided into treatment group(30cases)and control group(30cases).The control group was treated with the standard chemotherapyalone.Thetreatmentgroupwastreatedwithstandard chemotherapyandtheprescriptionofremovingbloodstasisand detoxification.The treatment lasted 4 cycles(84days).The tumor size,KPS,EOCG,lung cancer survival quality,blood coagulation function,immune indexes and biochemical indexes were taken as the main curative effect evaluation indexes and all datas were statistically anaiyzed.Results:(1)Thecomparison ofclinical efficacy:After 84 days’treatment,the effective rate composed of treatment group was 63.3%,which was higher than 56.6%in control group.There were no significant difference in the efficacy of two groups by chi-square test(P>0.05).The disease stability rate of treatment group is 83.3%,which was higher than 80.0%in control group.There were no significant difference in the efficacy of two groups by chi-square test(P>0.05).It showed clinical efficacy of treatment group was higher than that in control group while the difference was no significant.(2)ECOG scores comparison:The effective rate of treatment group was86.7%,which was higher than 80.0%in control group.There were no significant difference in the efficacy of two groups by chi-square test(P>0.05).It showed ECOG scores of treatment group was higher than that in control group.(3)Life quality comparison of lung cancer patients:After treatment,the treatment group showed highly significant improvement in physiologic condition(P<0.01),andthecontrolgroupalsoshowedsignificantly improvement(P<0.05).Thetreatmentgroupshowedsignificantly improvement in emotional and function status(P<0.05).The additional status of the two groups showed no significant difference after treatment(P>0.05).All of the above indicated that the treatment group showed much more effective in improving the life quality of NSCLC than the control group.(4)Comparison of TCM syndrome integral:Before treatment,the difference betweencontrolgroupandtreatmentgroupwerenosignificant(P>0.05).After treatment,the difference between the two groups showed significantly(P<0.05).Comparedwithbeforeandaftertreatment,the difference showed highly significant(P<0.01).All of the above indicated that the treatment group showed much more effective in improving the TCM syndrome integral of patients with lung cancer than in the control group.(5)Comparison of KPS scores:Before treatment,there were no statistically significant difference between the two groups(P>0.05).After treatment,the difference between the two groups were statistically significant(P<0.05)byχ~2test.TheKPSscoresofcontrolgroupandtreatmentgroup were(77.33±5.83)and(81.00±5.47).Itshowedstatisticallysignificant difference between the two groups(P<0.05)by t test.Compared with before and after treatment,the difference showed highly significant(P<0.01)by t test,which indicated that the treatment can improve the KPS scores.(6)Comparison of immune indicators:There were no differently between CD4+cells,CD8+cells,CD4+/CD8+before treatment(P>0.05).After treatment,the two groups were significantly different(P<0.05),and the CD4+cells in the treatment group also increased significantly after treatment(P<0.05),and the control group showed no differently before and after treatment(P>0.05).The CD8+cells in the treatment group decreased highly significant after treatment(P<0.01).After treatment,CD4+/CD8+was higher in both the treatment group and the control group,but the treatment group was significantly higher than the control group(P<0.01).The results showed that both the treatment group and the control group had improved immune function,and the improvement of immune function in the treatment group was more significant and statistically significant.(7)The coagulation function of the two groups and the change of D-D:According to the comparison results of the two groups,the PT in the treatment group and the control group increased before the treatment,but no statistical significance(P>0.05).APTT and TT in the treatment group were all increased after treatment(P<0.05).There was no significant difference in TT treatment in the control group,but APTT increased.The Fib of the treatment group decreased highly significant after treatment(P<0.01),while the control group showed no significantly difference before and after treatment.D-D decreased in both the treatment group and the control group(P<0.05).It was indicated that the treatment group has obvious regulating effect on the coagulation function and D-D of NSCLC.(8)Changes in safety indicators:Changes in patients’blood:WBC and PLT were reduced after treatment,while the decrease of RBC and Hb wasn’t obviously.The control group was reduced in WBC,RBC,Hb and PLT after treatment,and the WBC,Hb and PLT decreased highly significant(P<0.01).The results showed that the control group had a significant inhibitory effect on hematopoietic system.Liver and kidney function:After treatment,the ALT of the treatment group was significantly higher than before(P<0.05).In the control group,ASL,ALT were significantly higher after treatment than before treatment(P<0.05).Cr,BUN index in no difference before and after the treatment(P>0.05).It showed that the liver function damage was lower in the treatment group than in the control group.Conclusions:In the treatment of phlegm and blood stasis mutual junctionadvanced NSCLC,in comparison with NP chemotherapy,Huayu Jiedu method combined DP scheme chemotherapy had equivalent effects in clinical efficacy,ECOG scores,blood coagulation function,D-D,but it had been better in KPS score,TCM syndrome,Immune function and safety. |
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