Comparison Of The Clinical Efficacy Of CO₂ Laser And Open Surgery In The Treatment Of Anterior Combined T1N0 Glottic Carcinoma

objective: To compare the curative effect of the CO 2 laser surgery and traditional open surgery in the treatment of T1N0 glottic squamous cell analysis,and to make clear the best surgical method for the treatment of T1n0 laryngeal squamous cell carcinoma with anterior invasion.Methods: To select the Shenzhen second People’s Hospital,Shenzhen People’s Hospital,Peking University Shenzhen Hospital ent Department from January 2010 to December 2016 all of the glottis laryngeal cancer patients 235 people,and finally in accordance with the criteria and exclusion criteria strictly screened before the invasion of T1n0 Glottis laryngeal carcinoma 54 people.Among them,2 females,the rest were male;age 35~75 岁,median age 61 years.Among them,CO 2 laser surgery was the observation group and open surgery was the control group.The clinical case data were analyzed retrospectively.Results: The follow-up time was 11-93 months and median was 38 months.2 cases of recurrent death,loss of 1 cases(by death),total survival os 94.4%(51/54),the observation Group three-year cumulative survival rate of 93.8%(15/16),five-year cumulative survival rate of 100%(4/4),control Group Three-year cumulative survival rate of 92.9%(13/14),Five-year cumulative survival rate was 100%(8/8)with no statistically significant difference.The total recurrence rate of t1n0 laryngeal carcinoma was 16.7%(9/54),the observation group was 23.1%(6/26),the control group was 10.7%(3/28),and there was no statistically significant difference between the two groups(x2=1.484,p>0.05).The survival rate of three years was 86.7%(26/30),the observation group accounted for 81.3%(13/16),the control group accounted for 92.9%(13/14),there was no statistically significant difference between the two groups(p>0.05).In the observation group,the average hospitalization day was 7.6 days,the average hospitalization day of the control group was 15.6 days,the difference was statistically significant(p<0.01).The blood volume of the observation group was about 10 ml,which was significantly lower than that of the control group,and the difference was statistically significant.The average hospitalization cost of the observation group was(10500.52±3315.84),the average hospitalization cost of the control group was(23093.22±8212.29),and the difference of the two groups was statistically significant(p<0.01).In the observation group,the score of Voice disorder index was lower,the normal rate was 9.6% higher than that in the control group,statistically,the difference of the two groups was statistically significant(p<0.05).In the two groups,the quality of Life questionnaire in Washington was not statistically significant(p>0.05),and the scores of pain,emotion and anxiety were significantly different from those of the control group(p<0.01),while the score of mastication,swallowing,taste,shoulder function,vigor,saliva score and the control group were significant.The score of language was statistically significant compared with the control group.(p<0.01).Conclusion: The survival rate and local control rate of t1n0 laryngeal carcinoma combined with CO2 laser and open operation are similar,but the former is in short hospitalization time,less bleeding in operation,good voice quality and high quality of life,which is worth popularizing in clinical application.