The Application Of Optic Disc Capillary Network Density In The Diagnosis And Follow-up Of Primary Glaucoma By Optical Coherence Tomography Angiography

Objective:By using optical coherence tomography angiography,clarify the correlations among optic disc capillary network density and retinal nerve fibre layer(RNFL)thinkness and mean deviation of visual field and mean cup disc ratio in primary glaucoma.To explore the role of this technique in the early diagnosis of glaucoma and monitor of the condition of the disease.Methods:In this study,we collected 97 eyes of 61 subjects diagnosed with primary glaucoma who visited the Department of Ophthalmology of the Second Hospital of Hebei Medical University between January 2017 to February 2018.They were divided into acute-angle closure glaucoma group,chronic angle-closure glaucoma group and primary open angle glaucoma group.The image of optic disc capillary network,RNFL thickness and mean cup disc ratio were collected by Angio-OCT.Image J was used to calculate the capillary network density in the cup disc image,and the mean deviation(MD)was obtained by using the full automatic perimeter to detect the visual field.Results:Acute angle-closure glaucoma group:the optic disc capillary network density was 0.13±0.07%,RNFL thickness was 104.04±14.00μm,MD was 8.68±6.52 dB,the mean cup disc ratio was 0.57±0.19;chronic angle-closure glaucoma group:the optic disc capillary network density was0.12±0.06%,RNFL thickness was 104.08±17.12μm,MD was 7.05±6.37 dB,the mean cup disc ratio was 0.57±0.20;primary open angle glaucoma group:the optic disc capillary network density was 0.15±0.05%,RNFL thickness was 111.71±9.16 μ m,MD was 5.30±4.37 dB,the mean cup disc ratio was 0.53±0.16.Significant positive correlations were found between optic disc capillary network density and optic disc RNFL thickness(P <0.05),significant negative correlations were found between optic disc capillary network density and MD and mean cup disc ratio(P < 0.05)by pearson correlations text in three group.Conclusions: There is a clear correlation between optic disc capillary network density and optic disc RNFL thickness and MD and mean cup disc ratio in patients with primary glaucoma,the optic disc capillary network density can be used as reference for the diagnosis and follow-up of primary glaucoma.