Golgi Glycoprotein-73 In Primary Liver Cancer Diagnostic Value And Clinical Significance

ObjectiveTo explore the diagnostic value and clinical significance of Golgi glycoprotein-73 in primary liver cancer,chronic hepatitis and liver cirrhosis,in order to provide some theoretical guidance for the evaluation and treatment of the patients with primary liver cancer,and to provide a reliable laboratory basis for the clinical individualized immunotherapy.MethodThe patients in our hospital in last two years were randomly divided into four groups.45 cases of primary liver cancer were group PHC,38 cases of liver cirrhosis were group Cirrhosis,32 cases of chronic hepatitis patients were group Hepatitis and 11 cases of liver benign tumor were group benign.The serum GP73 protein concentration was detected by ELISA enzyme-linked immunosorbent assay(ELISA).Serum AFP concentration was detected by Electrochemiluminescence.The data were analyzed by SPSS statistical software,and the sensitivity,specificity and the curve area under the line were compared,and the relationship between GP73 and the clinical case parameters of liver cancer was analyzed.ResultThe results showed that:(1)the GP73(295.74 + 125.49 g/L)in the PHC group was significantly higher than that in the cirrhosis group(178.72 + 69.82 g/L),the hepatitis group(95.29 + 42.44 mu g/L),the benign group(98.76 + 51.62 u g/L)(P<0.05),the difference between the multiple and two groups was significant and statistically significant;(2)In 17 AFP negative patients,the positive rate of GP73 was 58.8%(10/17).In AFP positive patients,the positive rate of GP73 was 96.4%(27/28),which indicates that GP73 is of great significance for the PHC diagnosis of negative AFP detection.(3)For PHC diagnosis,GP73 sensitivity was significantly higher than AFP 62.2%(28/45)(P<0.05),specificity 60%(48/80)was less than AFP 86.25%(69/80).According to ROC curve,the AUC difference between the two were not obvious,statistically meaningless.(4)The concentration of GP73 was associated with cirrhosis,portal vein thrombus and tumor staging(P<0.05),which was statistically significant;it was not related to sex,age,tumor volume and metastasis degree,ascites,and statistically meaningless.ConclusionCompared with the traditional AFP,GP73 has a higher sensitivity in the diagnosis of PHC,which can help clinicians to judge the patient's condition accurately.It can obviously improve the accuracy of the diagnosis of PHC and avoid the leakage.GP73 is associated with vascular invasion and tumor staging in patients with liver cirrhosis,which may be associated with hepatocyte destruction,infiltration,and tumor load,and more experiments are needed to further verify.