Analysis Of Influencing Factors Of Pepsinogen And Gastrin 17 In Middle-aged And Elderly Patients With Chronic Non-atrophic Gastritis

According to endoscopic and histopathological,chronic gastritis can be divided into chronic atrophic gastritis and chronic non-atrophic gastritis.It's a common disease which refers to various types of chronic gastric mucosal inflammatory changes,and the chronic non-atrophic gastritis is the majority.Serum pepsinogen combined with gastrin 17 can reflect various types of chronic gastritis,determine whether is precancerous lesions,as a screening indicator of gastric cancer,and be used to monitor the effect of CNAG treatment.To explore the impact of related factors on the expression of serum PG and G-17 will help us further evaluate the clinical significance of the above indicators objectively.Objective:To explore the relationship between serum pepsinogen(PG)and gastrin-17(G-17)in age,sex,Helicobacter pylori(H.pylori)infection,smoking,drinking and other related factors in middle-aged and elderly patients with chronic non-atrophic gastritis.Methods:A total of 667 subjects,who were the patients with chronic non-atrophic gastritis in the first central hospital of Baoding,were collected in this study.Serum PG and G-17 levels were measured by enzyme-linked immunosorbent assay(ELISA).H.pylori status was determined by 13 C breath test.Comparison between the two samples using Wilcoxon test.Results:1.The serum PGI and PGII levels were increased with age(p < 0.01;p < 0.01),while the PGR was significantly reduced(p < 0.01).2.The serum PGI and PGII levels were significantly higher in males than in females(p < 0.01;p < 0.01),while the PGR was significantly lower in males than in females(p < 0.01).3.The serum PGI and II levels were significantly higher in patients with H.pylori infection than in those without H.pylori infection(p < 0.01;p < 0.01),while the PGR was significantly lower in patients with H.pylori infection than in those without H.pylori infection(p < 0.01).4.The serum PGI,II and the PGR levels were significantly higher in the smoking group than in the non-smoking group(p < 0.01;p < 0.01;p < 0.01).The level of PGI,PGII and PGR were higher in the drinking group than non-drinking group(p < 0.01;p < 0.01;p < 0.01).5.The serum G-17 were higher in H.pylori positive than in H.pylori negative(p < 0.01)and there were no differences between the other factors.Conclusion:In the population of middle-aged and elderly patients with chronic non-chronic gastritis,the level of serum PG might have some relations with age,sex,H.pylori infection,smoking and drinking,and G-17 is only associated with H.pylori infection.