Current Status And Progress In Surgery For Adult Glioblastoma

Glioblastoma is the most common primary intracranial tumor,glioblastoma is a disease that cannot be treated by surgery alone,while the maximum range of surgical resection,and subsequent radiotherapy and chemotherapy,but the prognosis is still poor,Gross total resection safely can significantly increase progression-free survival and overall survival.The histological properties of the infiltrating growth of GBM makes total eradication impossible.Even to total removal of solid tumors,because of the existence of brain tumor stem cells,its heterogeneity and dormant nature can also lead to evasion of treatment,contribute to recurrence and malignant tumor progression,and severely impacting the survival of patient.So visual delimitation by surgical techniques to the edge of the tumor is a challenge faced by many surgeons,in an attempt to achieve the best security resection,intraoperative analysis of tumor and non-tumor tissue have been developed and applied in surgery of tumors and the tumor tissue analysis technology has been gradually developed and gradually applied in clinical resulting in improved outcomes,In addition,stimulation techniques during awake craniotomy can be used to define the eloquent areas,thus optimizing the degree of excision of gliomas in eloquent areas.This review will show the current standard therapy for the newly diagnosis and recurrent glioblastoma,this article focuses on the current surgical techniques which has been applied to clinical,such as awake craniotomy,intraoperative neural navigation,intraoperative MRI,fluorescence guided surgery,laser interstitial thermal therapy,intraoperative mass spectrum etc.In addition,the intraoperative optical coherence tomography of tumor tissue showed promising results in preclinical trials.