Meta Analysis On Diagnosis Value Of Narrow Band Imaging And Iodine Staining In Early Esophageal Cancer And Precancerous Lesions

Objective:To systematically evaluate the value of narrow band imaging(NBI)and iodine staining in early diagnosis of esophageal cancer and precancerous lesions.Methods:The databases of CNKI,PubMed,VIP technological journals,Embase and Wanfang digital journals were retrieved by computer for searching the literatures on the value of NBI and iodine staining in diagnosing early esophageal cancer and precancerous lesions.The Meta-Disc 1.4 software was used to conduct the meta analysis and calculate the pooled sensitivity,specificity and 95%confidence interval(95%CI).Summary receiver operating characteristic(SROC)curve was drawn and the area under curve(AUC)was calculated,thus the diagnostic values of the two methods were evaluated.Results:Totally 13 articles were included,including 975 patients.The pooled sensitivity for NBI was 0.88(95%CI=0.86 to 0.90),and the pooled specificity for NBI was 0.79(95%CI=0.76 to 0.82).The pooled sensitivity for iodine staining was 0.95(95%CI=0.93 to 0.97),and the pooled specificity for iodine staining was 0.45(95%CI=0.40 to 0.49).AUC of SROC for NBI was 0.9386,respectively AUC of SROC for iodine staining was 0.9529.There was no statistically difference in the AUC values between the two methods(Z=0.519,P>0.05).Conclusion:NBI and iodine staining are both effective ways in the diagnosis of early esophageal cancer and precancerous lesions.And both of them have a certain clinical value.