Muscle Mass May Improve Peripheral Nerve Conduction Velocity In Patients With Type 2 Diabetes

Aims: This study investigates the association between the changes of muscle mass and the improvement of nerve conduction velocity in type 2 diabetes mellitus.Methods: A total of 1838(937 man and 901 woman)type 2 diabetes were recruited from the First Affiliated Hospital of Fujian Medical University,with a mean age of 60.33±11.47 years.The data integrity of 183 follow-up patients were enrolled,with a mean age of 59.08±9.88 years,and median follow-up time was 27 months.All participants underwent body component as well as sensory and motor nerve conduction velocity(NCV)measurement,and calculating the composite Z scores for sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV).To compare the relationship between the change of muscle mass index and the improvement of nerve conduction velocity at the end of follow-up period.Result:The muscle mass index of men with type 2 diabetes was positively associated with the motor of median NCV,ulnar NCV,peroneus NCV,tibial NCV and the sensory of median NCV,ulnar NCV,peromeal NCV,sural NCV as well as the composite Z scores of MNCV and SNCV.After adjusting for age,BMI,drugs and other confounding factors,the correlation with the composite Z scores of MNCV(?(95%CI)0.224(0.142-0.305))and SNCV(?(95%CI)0.332(0.215-0.449))remained significant.But momen did not find the relationgship after adjusting for these confounding factors.Compared with the muscle mass reduction of >3% group during the follow-up period,the detection rate of nerve conduction velocity of muscle mass increased of >3% group was increased(P<0.05),the nerve conduction velocity increased obviously in the motor of median NCV,ulnar NCV,tibial NCV and the sensory of median NCV,ulnar NCV,peromeal NCV,sural NCV as well as in the composite Z scores of MNCV and SNCV(OR(95%CI)respectively 0.297(0.091-0.962),0.095(0.024-0.368)).But momen did not find the relationgship in the composite Z scores of MNCV and SNCV.Conclusion:There were gender differences in the reletionship between muscle mass and nerve conduction velocity in patients with type 2 diabetes,Increased muscle mass may improve partial motor and sensory nerve conduction velocity.