The Analysis For The Risks Of Recurrence And Survival Of Hepatocellular Carcinoma After Microwave Ablation Guided By Ultrasound

Purpose:To research the clinical efficacy of microwave ablation guided by ultrasound in the treatment of hepatocellular carcinoma by following-up in 1^st Hospital of Jilin University and analyze the related risk factors for outcomes.Material and method:Data of patients who underwent microwave ablation during July 2014 to November 2016 were collected.The data included general information of patients,pre-operational Child-Pugh classification,MELD score and ALBI grade.Oncology data including the largest diameter of tumors,the volume of tumors and the location were recorded.The ablative power,time,energy and the number of needle tip placement were recorded.All the patients were followed up after ablation.Overall survival?OS?,overall survival rate?OSR?,disease-free survival?DFS?,disease free survival rate?DFSR?and local tumor progression rate?LTPR?were analyzed with Kaplan-Meier method and independent risk factors were analyzed with Cox regression.Result:222 patients with 288 tumors were brought into this research while 8 patients were lost during follow-up period.Follow-up period was16.10 to 43.83 months.The average follow-up period is at 27.94±8.01 months and the median was 27.10 months.There were 72 new tumor recurrences,10/288?3.6%?local tumor progression and 9deaths observed during follow-up.The 12-months-OSR was 100%,the 24-months-OSR was 98.82%,the 36-months-OSR was 93.08%.The average OS was 42.44 months.The 12-month DFSR was 80.3%,24-month-DFSR was 66.2%and 36-month-DFSR was 58.8%.The average DFS was 31.67 months.The volume load of tumors over9.66cm³ and ALBI Grade 3 were independent risk factors for survival?P=0.016,P?27?0.001?.Liver cirrhosis was the independent risk factor for intrahepatic recurrence?P=026?.The diameter or the volume was the independent risk factors for local progression?P?27?0.01,P=0.016?.Conclusion:Microwave ablation was an effective method to treat HCC.The volume load of tumors and ALBI Grade were independent risk factors for survival.Liver cirrhosis was the independent risk factor for intrahepatic recurrence.The largest diameter and volume of tumors were independent risk factors for tumor local progression.