The Independent Prognostic Factors Affecting Metastasis And Recurrence Of Small Hepatocellular Carcinoma And The Comparison Between Hepatectomy And Microwave Ablation

Objective To study the independent prognostic factors affecting the metastasis and recurrence of small hepatocellular carcinoma. To compare the influence of hepatectomy and microwave ablation on the metastasis and recurrence of small hepatocellular carcinoma and the influence on liver function, changes of serous concentration of growth factors and cell-mediated immunity. Methods(1) The metastasis and recurrence of 194 patients with one HCC of diameter ≤ 5cm who underwent curative hepatic resection or microwave ablation between January 1995 and December 2001 were reviewed retrospectively; Immunohistochemistry was used to analyse the expressions of VEGF,bFGF and c-Met in HCC tissues. Posttreatment prognostic factors were evaluated by univariate and multivariate analysis using Cox's proportional hazards model. The variables included the expressions of these three proteins, the clinical and pathologic characteristics of the patients.(2) The metastasis and recurrence of 28 patients underwent curative hepatic resection and 20 patients underwent microwave ablation with one HCC of diameter ≤ 5cm between February 2004 and May 2005 were studied prospectively and then the prognostic factors were further demonstrated.(3) Liver function, serous concentration of VEGF, HGF and TGF-β1 and cell-mediated immunity after curative hepatic resection or microwave ablation were assayed with the methods of ELISA or flow cytometry and the results in the two groups were compared.Results:(1) The retrospective study showed that the 1, 3, 5-year disease-free survival...