| Background:As one of the most common,distressful and persistent symptoms in cancer patients receiving chemotherapy and/or radiotherapy,cancer-related fatigue(CRF)is of high-incidence,prolonged and even could last for several years after the completion of anti-cancer treatment.CRF could decrease patients' quality of life,aggravate anxiety and depression,in addition,it could even affect patients' adherence to treatment.Previous researches indicated that aerobic exercise can alleviate patients'CRF,enhance physical function,improve mental status and quality of life.However,there's few systematic researches.Thus,it's meaningful to explore the effect of exercise intervention on CRF in gynecological cancer patients.Objectives:To investigate the effect of exercise intervention on CRF in gynecological cancer patients receiving chemotherapy.Methods:A quasi-experimental study was conducted.A convenient sample of 96 women firstly diagnosed with gynecological cancer patients requiring chemotherapy from Peking Union Medical College Hospital was enrolled.They were divided into intervention group(N=48)or control group(N=48)according to the time sequence of admission.Both groups were provided with health education about CRF besides usual care.Pamphlets about exercise intervention and exercise diary were distributed.Besides,the intervention group was provided exercise intervention,combing brisk walking and elastic band resistance exercise in the hospital before every chemotherapy circle.Follow-up phone calls and Wechat were conducted every week.Data were collected before every circle of chemotherapy and 6 measuring points were included.Outcome measures were CRF and exercise capacity that was reflected through post-test patient-reported fatigue and 6-minute walk distance(6MWD).Results:90 women completed data collection,45 women in intervention group and 45 in control group.CRF in total and four dimensions were analysed respectively.Fatgiue level in both groups ascended constantly,nonetheless with smaller scope in the intervention group.After the competition of intervention,CRF in intervention group was significantly lower than control group(P<0.01).Similiarly,6MWD in both groups descended continuously with the smaller scope in intervention groups.After the intervention,6MWD in intervention group was significantly longer than control group(P<0.01).However,there were no statistically significant differences in post-test patient-reported fatigue(P>0.01).Conclusion:Exercise intervention can reduce CRF in gynecological cancer patients receiving chemotherapy and slow the decrease of exercise capacity caused by cancer and chemotherapy. |
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