Research On Effects On Intestinal Permeability Of T-tube Drainage And Primary Suture After Laparoscopic Common Bile Duct Exploration

Objective:This study aims to explore effects of primary suture(PS)and T-tube drainage(TD)on intestinal permeability after laparoscopic common bile duct exploration(LCBDE).Methods:90 patients were grouped as PS and TD subject to their will.Urine as well as peripheral blood was collected at 1 day pre-op and 2 days past-op.The high pressure liquid chromatography method and spectrophotometer were respectively used to detect urinary lactulose/mannitol(L/M)and plasma diamine oxidase(DAO).Patients' intestinal permeability was measured by detection results.Results:The pre-op and past-op L/M index of PS group were(0.090±0.011)and(0.128±0.028).The pre-op and past-op L/M index of TD group were(0.098 ±0.048)?(0.246±0.187).The pre-op and past-op DAO index of PS group were(1.712±0.252)U/mol?(1.881 ±0.351)U/mol.The pre-op and past-op DAO index of TD group were(1.781±0.482)U/mol?(2.363±0.187)U/mol.The increase of both L/M and DAO index in TD group were more substantial than PS group.Conclusion:Both two Surgical methods lead to increase of intestinal permeability.However,the increase after PS is less than that after TD.