The Expression And Prognostic Value Of SOX2、β-catenin And Survivin In Esophageal Squamous Cell Carcinoma

Objective:SOX2,as an important nuclear transcription factor in SOX gene family,activates Wnt signaling pathway by binding with β-catenin,triggers TCF/LEF/β-catenin cascade reaction and activates transcription of downstream target genes Survivin et al.We explored the expression of SOX2 、 β-catenin and Survivin,and the effect of SOX2 、β-catenin and Survivin on prognosis in esophageal squamous cell carcinoma(ESCC).Methods: Immunohistochemistry was used to examine the expression of SOX2 、β-catenin and Survivin.Chi-square test analyses the relationship between SOX2 、β-catenin 、 Survivin and pathological parameters.Spearman correlation analyse the relationship between three proteinsnin.Kaplan-Meier Survival Analysis and Cox Proportional Risk Model were used to investigate the effect of SOX2 、β-catenin and Survivin on prognosis.Results:SOX2 positivity was related to lymph node metastasis(P=0.004)and vascular invasion(P=0.041).β-catenin positivity was associated with the depth of invasion(P=0.014)and lymph node metastasis(P=0.032).Survivin positivity was related to gender(P=0.022)and nerve invasion(P=0.014).There was a positive correlation between SOX2 and β-catenin(R=0.265,P=0.002).In addition,the expression of SOX2 and β-catenin in high grade intraepithelial neoplasia of esophagus and ESCC was significantly different.(P=0.049,R=0.354;P=0.013,R=0.446).Through Kaplan-Meier survival analysis,patients with SOX2 and β-catenin high expression had poor prognosis in ESCC.In addition,Survivin positive patients had a shorter survival time in patients who received postoperative chemoradiotherapy.Conclusion:SOX2 andβ-catenin are closely related to the occurrence and development of ESCC.SOX2 may affect the prognosis of ESCC patients by regulating the expression of β-catenin,while patients with positive expression of Survivin protein are more prone to drug resistance.