Clinical Effect And Quality Of Life Of Patients With Gastroesophageal Reflux Cough Treated By Soothing Lung And Reducing Adverse Reactions

Objective:To observe the clinical effect of "Sangxuan Decoction" on gastroesophage al reflux cough and its influence on patients'quality of life,and explore a new method to improve the curative effect of traditional Chinese medicine on gastroesophageal reflux cough.Methods:From January 2018 to December 2018,60 patients with gastroesophageal reflux cough were randomly divided into two groups:traditional Chinese medicine group and Western medicine group,30 in each group.The treatment group was given "Sangxuan Decoction" orally,while the control group was given omeprazole orally for 4 weeks as a course of treatment,and two courses of treatment were observed.The cough score,gastroesophageal reflux score,total score of gastroesophageal reflux cough symptoms,cough quality of life score(Leicester Cough Quality of Life Questionnaire,LCQ Question naire),cough psychological score and recurrence rate after 6 months of withdrawal were observed before and after treatment.RESULTS:1.Cough score:Compared with before treatment,the treatment group had significant improvement in day cough score,night cough score and total cough score(P<0.05?0.01)after 4 and 8 weeks of treatment,while the control group had night cough score,total cough score and total cough score after 8 weeks of treatment.There was significant improvement effect(P<0.05?0.01),and there were significant differences in three cough scores between the treatment group and the control group at 4 and 8 weeks after treatment(P<0.05?0.01).(2)Gastroesophageal reflux score:Compared with before treatment,acid reflux score,belching score,heartburn score and total gastroesophageal reflux score of the two groups were significantly improved after 4 and 8 weeks of treatment(P<0.05?0.01);after treatment,there was no significant difference in total acid reflux score,heartburn score and total gastroesophageal reflux score between the two groups(,P>0.05).(3)Cough quality of life:Compared with before treatment,the LCQ score of treatment group improved significantly after 4 and 8 weeks of treatment(P<0.05?0.01),and that of control group improved significantly after 8 weeks of treatment(P<0.05);after 4 and 8 weeks of treatment,the LCQ score of treatment group and control group ha d significant difference(P<0.05).(4)Cough Psychological Score:Compared with before treatment,the treatment group improved significantly after 4 and 8 weeks of treatment(P<0.01),while the control group improved significantly after 8 weeks of treatment(P<0.01);there were significant differences in the treatment group's psychological score after 4 and 8 weeks of treatment compared with the control group(P<0.01).Recurrence rate:After 6 months of treatment,the recurrence rate of the treatment group was 19.05%(4/21),and that of the control group was 50%(10/20).The recurrence rate of the treatment group was lower than that of the control group(P<0.05).CONCLUSION:The treatment group can effectively improve the symptoms of coug h and reflux in patients with GERC,while the control group can improve the symptoms of reflux and cough.The treatment group can improve the quality of life and the psychological status of cough in patients with GERC,which has certain advantages over the control group.The treatment group can reduce the recurrence of GERC effectively.