| Objective:The study aims at treating bradymenorrhea patients which caused by PCSD(Previous Cesarean Scar Defect)with the method of Qi-Tonifying and Heat-clearing and blood stasis-removing,observing the clinical efficacy of this method,discussing the possible mechanism of this method in treating PCSD,which may find an effective and safe way in recovering PCSD conservatively and provide a better clinical basis and idea for the treatment of'bradymenorrhea which caused by PCSD in the future.Methods:A total of 60 cases with PCSD patients who visited the Affiliated Hospital of Nanjing university of Traditional Chinese Medicine clinic from March 2017 to December 2018 were randomly divided into treatment group and control group.There is no statistical difference in their age,the course of the disease,the number of cesarean section and the time from the latest cesarean section till now in both two groups.Treatment group were given traditional Chinese medicine which under the method of the Qi-Tonifying and Heat-clearing and blood stasis-removing,while the control group were given Diane-35(Ethinylestradiol and Cyproterone Acetate Tablets,Bayer HealthCare,Registration numbers:H20090503).After a course of treatment,which is 3 menstrual cycles,we observe the changes in menstruation,clinical symptoms and the volume change of uterus incision lacuna under b-ultrasound,record the changes of safety index and the adverse effect and statistically analyze the dataResults:?On the aspects of menstrual time:The menstrual time of both two groups was shorter than before after 1 and 4 months intervention,P<0.05,with significant difference of statistical significance.Make comparison between the two groups,1 month after the end of intervention,the control group was better than the treatment group.While 4 months after the end of intervention,the menstruation time of the treatment group was shorter than control group,with no significant difference.?On the aspects of menstruation total score:The menstruation total score of both two groups was obvious lower than before after 1 and 4 months intervention,P<0.05,having statistical significance.Make comparison between the two groups,1 month after the end of intervention,there is no significant difference between two groups.4 months after the end of intervention,the menstruation total score of treatment group was lower than control group,P<0.05,with significant difference of statistical significance.?On the aspects of TCM syndrome score:The TCM syndrome scores of both two groups were lower than before after 1 and 4 months intervention,P<0.05,with significant difference of statistical significance.Make comparison between the two groups,both land 4 months after the end of intervention,the TCM syndrome scores of treatment group was less than control group,P<0.05,with significant difference of statistical significance.?On the aspects of TCM therapeutic efficacy:1 months after the end of intervention,the TCM therapeutic efficacy rate of the treatment group and the control group was 93.33%and 80%respectively.4 months after the end of intervention,the TCM therapeutic efficacy rate of the treatment group and the control group was 100%and 73.33%respectively.Make comparison between the two groups,1 month after the end of intervention,there is no significant difference of statistical significance.While 4 months after the end of intervention,the TCM therapeutic efficacy rate of the treatment group was higher than the control group,P<0.05,with significant difference of statistical significance.?On the aspects of symptom total score:The symptom total score of both two groups were lower than before after]and 4 months intervention,P<0.05 with significant difference of statistical significance.Make comparison between the two groups,both land 4 months after the end of intervention,the symptom total score of treatment group was lower than control group,P<0.05,with significant difference of statistical significance.?On the aspects of the volume change of uterus incision lacuna and curative effect:After the treatment,the width and depth of uterus incision lacuna of both two groups were smaller than before,P<0.05.On the aspects of narrow the depth of uterus incision lacuna,the treatment group was better than the control group,P<0.05,with significant difference of statistical significance.On the aspects of the curative effect of changing uterus incision lacuna,the treatment group was 16.67%,the control group was 10%.Make comparison between the two groups,there is no significant difference of statistical significance.?On the aspects of total clinical efficacy:The total clinical efficacy rate of the treatment group and the control group was 86.67%and 70%respectively.Make comparison between the two groups,there is no significant difference of statistical significance.Conclusion:Both the groups can achieve the purpose of treatment by reducing the volume of uterus incision lacuna,improving prolonged menstrual period and clinical symptom score.I month after the end of intervention,the menstrual time of the control group was shorter than the treatment group,but the treatment group have better outcome in menstruation total score,TCM syndrome score and symptom total score.4 months after the end of intervention,the menstrual time of the control group increased compared with 1 month after the end of intervention,the menstruation total score and the symptom total score also increased.On contrary,the menstrual time,the menstruation total score and the symptom total score of the treatment group decreased compared with 1 month after the end of intervention,and the treatment group had better outcome in reducing the depth of uterus incision lacuna,improving prolonged menstrual period and TCM syndrome.There was no adverse reaction and side effect during the clinical trials,indicating that the method of Qi-Tonifying and Heat-clearing and blood stasis-removing is an effective and long-lasting way to treat the bradymenorrhea which caused by PCSD.It can be used in clinical practice. |
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