| Objective: To observe the effect of enteropathy prescription on IBS-D patients with wet stagnation bowel syndrome,TCM symptom score,anxiety scale,recurrence rate,and the effect of serum 5-hydroxytryptamine(5-HT)and vasoactive enteropeptide(VIP)before and after the treatment of patients with intestinal diseases,so as to provide a reference for the treatment of ibs-d with traditional Chinese medicine.Methods: Taking the outpatients and inpatients in the department of gastroenterology of Ruikang hospital affiliated to guangxi university of traditional Chinese medicine from December 2017 to September 2018,60 patients who met the diagnosis of ibs-d dampness-stagnation bowel syndrome were selected and randomly divided into two groups(30 patients in each group).Group A was the control group and group B was the treatment group.The control group was treated with a combination of two western drugs,trimebutin maleate dispersible tablets and bifidobacterium trifecta capsules.On the basis of the control group,the treatment group was instructed to follow the principles of light diet in the treatment process.Patients in both groups were given two consecutive courses of 2 weeks each.At the end of the two treatment courses,the changes of curative effect points,TCM syndrome points,life scale scores of IBS patients,anxiety(SAS)depression scale(SDS)scores,plasma 5-HT and VIP,and recurrence rate were compared between the two groups before and after treatment.Results: 1.After treatment,the total number of cases in the treatment group and the control group were compared,including 7 cases in the treatment group and 2 cases in the control group.18 patients in the treatment group and13 patients in the control group.The number of cases in the treatment group was 4,and the control group was 9,The number of invalid cases in the treatment group was 1 and the control group was 6.The total efficacy rate of the two groups after treatment was compared,and 83.33% of the treatment group was better than 50.00% of the control group(P<0.05).2.Comparison of TCM syndromes: after statistical analysis,the total collection points of the two groups showed no obvious difference(P>0.05).After treatment,the total score of the two groups is better than before treatment.(P < 0.05),while the total score of the comparison group after treatment was better than that of the control group(P < 0.05).The total effective rate of TCM syndrome treatment group was higher than that of control group(P<0.05).3.Comparison of life scale scores of patients with IBS between the two groups: the scores of 8 dimensions before and after treatment were compared,and the scores of 5 dimensions of anxiety,body role,diet,behavior disorder and health worry in the treatment group were better than those in the control group(P<0.05).4.Comparison of anxiety(SAS)depression scale(SDS)score: compared with anxiety scale(SAS)score,the treatment group was better than before treatment(P < 0.05).The comparison of the control group after and no significant difference before treatment(P>0.05).The treatment group was better than the control group(P < 0.05).The depression scale(SDS)after treatment was better than that before treatment in both groups(P < 0.05).Compared with the control group,the post-treatment score of the treatment group was better than that of the control group(P<0.05).5.Comparison of plasma 5-HT and VIP: the blood plasma 5-HT and VIP levels of the two groups after treatment showed no significant difference(P>0.05).After treatment,the plasma levels of 5-HT and VIP in both groups were better than that before treatment(P<0.05).Plasma 5-HT and VIP levels in the treatment group were superior to the control group(P<0.05).6.Comparison of recurrence rate: 1 month after the end of treatment,the patients in the two groups who were more effective than TCM syndrome were followed up.The follow-up showed that there were no recurrence in 25 patients,3 patients had recurrence,and the recurrence rate was 13.8%.In the control group,23 patients were followed up.13 patients were found to have no recurrence,and 10 patients had recurrence.The recurrence rate was 43%.The recurrence rate was lower in the experimental group than in the control group(P<0.05).7.No adverse reactions occurred in the two groups during the observation period.Conclusion: Chang bing fang can improve the symptoms of patients with IBS-D dampness and stagnation syndrome,improve the score of life table of patients with IBS,relieve anxiety and depression,and play a good role in regulating plasma 5-HT and VIP levels,and also reduce the recurrence rate of patients,it is worthy of clinical promotion. |
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