Predictive Value Of Neutrophil To Lymphocyte Ratio On Acute Myocardial Infarction

Objective:We aimed to define the severity of inflammation(NLR)by observing the association of NLR with cardiac functions or myocardial damage parameters in patients with acute myocardial infarction.Methods: Data from 200 patients who underwent percutaneous coronary intervention(PCI)within 72 hours of incidence in 2016 to 2019 were analysed retrospectively.Patients were divided into L-NLR(NLR<9.28)group and H-NLR(NLR≥9.28)group according to the median value of the neutrophil to lymphocyte ratio(NLR),and further divided into L-NLR(NLR<13.75)group andH-NLR(NLR≥13.75)group by using quartiles.The data between different groups of patients were compared and compared with the overall data to evaluate the differences of NLR in patients with ACS with different degrees of severity.Results: Among the 200 patients,163 were male and 37 were female,27~85 years old,with an average age of(57.67±12.16)years old.NLR positively correlated with myocardial damage(NLR vs.CK: p < 0.0001;NLR vs.CK-MB: p < 0.0001)but negatively correlated with myocardial function(NLR vs.EF: p <0.0001;NLR vs.FS: p < 0.0001).Myocardial damage markers(CK,CK-MB,ASL,LDH)were significantly increased,and cardiac contractile parameters(EF and FS)were reduced at NLR≥9.28 compared to those of NLR < 9.28.And it had been shown that IL-6,CRPH were significantly increased when NLR ≥ 13.75 and CRPHwas increased at NLR≥13.75.The correlation was diminished between NLR and CK-MB at NLR≥ 9.28 or at NLR≥13.75,but that of NLR and EF or FS was maintained in NLR ≥9.28 and at NLR≥13.75.EF and FS were comparable between NLR≥9.28 and NLR≥13.75.But myocardial damage parameters increased significantly at NLR≥13.75 compared to those of NLR≥9.28.Conclusion: NLR is a strong predictor of myocardial damage in acute myocardial patients.High NLR are associated with myocardial dysfunction in all the patients.Severe inflammation(NLR)can predict the consequence of the heart in patients with coronary syndrome.