A Study Identifies Expression Of Erap1, TNFR-Ⅰ And TNFR-Ⅱ In Psoriasis Vulgaris Lesions

Objective:To explore the possible role of ERAP1,TNFR-I,TNFR-II in the pathogenesis of psoriasis vulgaris.Methods:15 cases of normal skin and 20 cases of psoriasis vulgaris were enrolled.Immunohistochemical staining techniques were used to detect the expression of ERAP1 protein,TNFR-I protein,TNFR-II protein in the two groups.Statistical analysis was then performed to compare the difference in expression between the two groups.Results:(1)In normal skin,ERAP1 is mainly expressed in the basal layer of the epidermis.In the psoriatic vulgaris lesions,ERAP1 was diffusely positive.The expression of ERAP1 in the psoriatic lesions was stronger than that of normal tissues(Z=-4.010,P<0.05).(2)TNFR-I is diffusedly expressed both in the normal skin tissues and the psoriasis vulgaris tissues.However,in the epidermis of psoriatic lesions,the expression of TNFR-I in the spinous layer was stronger than that of the basal layer(?~2=17.740,P<0.05).(3)In the normal skin,TNFR-II was not expressed;in the psoriatic lesions,TNFR-II was diffusely expressed in the basal cell layer and acanthosis of the epidermis in varying degrees,and the difference between normal and psoriatic skin was statistically significant(?~2=17.500,P<0.001).(4)The expression of ERAP1 in the epidermis of psoriasis vulgaris was negatively correlated with TNFR-I(r_s=-0.662,P=0.001).There was no significant correlation between ERAP1 and TNFR-II(r_s=0.343,P=0.139).Conclusion:ERAP1,TNFR-I,and TNFR-II may play important roles in the pathogenesis of psoriasis vulgaris.Interactions between them may be able to regulate the proliferation and apoptosis of keratinocyte and maintain the abnormal,but benign proliferative state of the epidermis in psoriasis vulgaris.